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Autonomic dysregulation and self-injurious thoughts and behaviours in children and young people: A systematic review and meta-analysis

Bellato A 1 , Admani MA 2 , Deak C 3 , Farhat LC 3 , Fontana Antunes de Oliveira MC 3 , Vasconcelos R 4 Show all authors , Malanchini M 2 , Shephard E 3 , Michelini G 2

Affiliations 

  • 1 School of Psychology University of Nottingham Semenyih Malaysia
  • 2 Department of Biological and Experimental Psychology School of Biological and Behavioural Sciences Queen Mary University of London London UK
  • 3 Department of Psychiatry Faculdade de Medicina Universidade de São Paulo Sao Paulo Brazil
  • 4 Department of Psychology Health Sciences Center Universidade de Fortaleza Sao Paulo Brazil
JCPP Adv, 2023 Sep;3(3):e12148.
PMID: 37720589 DOI: 10.1002/jcv2.12148

Abstract

BACKGROUND: Self-injurious thoughts and behaviours (SITBs) have been associated with dysfunction of the Autonomic Nervous System (ANS) in children and young people, suggesting that objective ANS measures may aid assessment of suicide risk, but a systematic synthesis of this literature is currently lacking.

METHODS: Following a pre-registered protocol (PROSPERO CRD42022327605), we conducted a systematic search of PubMed, Medline, Embase, PsycINFO, and Web of Science, for empirical studies published until 10th May 2022 that compared indices of ANS functioning in individuals aged 0-25 years with versus without SITBs, or reported continuous associations between ANS measures and SITBs. Study quality was assessed with the Newcastle-Ottawa Scales. Pooled effect sizes (Hedge's g) were estimated with random-effects meta-analytic models.

RESULTS: Twenty studies (1979 participants) were included in our systematic review, with 16 included in meta-analyses. Results suggested that SITBs were associated with altered cardiac indices of arousal (g = -0.328, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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