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Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

Zhang HL 1 , Sandai D 2 , Zhang ZW 3 , Song ZJ 4 , Babu D 5 , Tabana Y 5 Show all authors , Dahham SS 6 , Adam Ahmed Adam M 7 , Wang Y 8 , Wang W 9 , Zhang HL 1 , Zhao R 4 , Barakat K 5 , Harun MSR 1 , Shapudin SNM 1 , Lok B 1

Affiliations 

  • 1 Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia
  • 2 Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia. doblin@usm.my
  • 3 School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 4 Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 5 Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton AB T6G 2E1, Canada
  • 6 Department of Science, University of Technology and Applied Sciences Rustaq, Rustaq 10 P.C. 329, Oman
  • 7 Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, United States
  • 8 Pathology Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 9 College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
World J Clin Oncol, 2023 Dec 24;14(12):549-569.
PMID: 38179405 DOI: 10.5306/wjco.v14.i12.549

Abstract

Adenosine triphosphate (ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer. This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis, deciphering the intricate mechanisms governing AICD, elucidating its intricate involvement in cancer signaling pathways, and scrutinizing validated key genes. Moreover, the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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