Affiliations 

  • 1 Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember Keputih, Sukolilo Surabaya 60111 Indonesia didikp@chem.its.ac.id
  • 2 Department of Chemical Engineering, Faculty of Engineering, Universitas Pembangunan Nasional "Veteran" Jawa Timur Surabaya East Java 60294 Indonesia
  • 3 Research Center for Biomass and Bioproducts, National Research and Innovation Agency of Indonesia (BRIN) Cibinong 16911 Indonesia
  • 4 Centre of Advanced Material and Energy Sciences, Universiti Brunei Darussalam Jalan Tungku Link BE 1410 Brunei
  • 5 Centre of Hydrogen Energy, Institute of Future Energy, Universiti Teknologi Malaysia 81310 Skudai Johor Bahru Johor Malaysia
  • 6 Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram Mataram 83125 Indonesia
RSC Adv, 2024 Jan 31;14(7):4509-4517.
PMID: 38312717 DOI: 10.1039/d3ra07113h

Abstract

Tautomerism alters the structure and properties of materials, which can be exploited to control their chemical and biological activities. The role of pH-induced tautomerism of polyvinylpyrrolidone (PVP) was determined by measuring the size, stability, and antioxidant and antibacterial properties of microwave synthesized-silver nanoparticles (AgNPs). TEM and XRD analyses confirmed the formation of face-centered cubic silver nanoparticles. PVP stabilized the AgNPs by interaction with the carbonyl or hydroxyl groups depending on the tautomerization under different pH conditions. At pH 4, PVP was stable in the keto tautomer, stabilizing Ag through electron donation of oxygen atoms in the carbonyl group, producing smaller AgNPs with a higher zeta potential. At pH 7 and 9, the enol tautomer PVP stabilized the AgNPs via oxygen atoms in the hydroxyl group, forming large nanoparticles. The keto form of PVP improved the stability and antioxidant and antibacterial properties of AgNPs compared with the enol form. This study also excluded the antioxidant contribution of PVP via hydrogen donation to free radicals. A facile method for controlling the size of AgNPs by adapting the pH-induced tautomerism of PVP that affects their stability and antioxidant and antibacterial activities is thus reported.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.