Optimizing protocols for monitoring in vivo replication of a novel chimeric Marek's disease vaccine with an insertion of the long terminal repeat of reticuloendotheliosis virus in the CVI988 strain genome (CVI-LTR)

Faiz NM 1 , Cortes AL 2 , Phang YF 3 , Gimeno IM 2

Affiliations 

  • 1 Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia
  • 2 Department of Population Health and Pathobiology, Veterinary School, North Carolina State University, Raleigh, NC, USA
  • 3 Boehringer Ingelheim Animal Health Singapore, Guoco Midtown, Singapore
Avian Pathol, 2024 Mar 20.
PMID: 38411905 DOI: 10.1080/03079457.2024.2324930

Abstract

CVI-LTR replicates in the thymus and spleen earlier than CVI988.CVI-LTR replicates in lymphoid organs but it cannot be detected in feather pulp.CVI-LTR reduced the load of oncogenic MDV DNA more efficiently than CVI988.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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