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Method Validation for Analysis of Simvastatin in Human Plasma Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS)

Alakhali KM 1

Affiliations 

  • 1 (a) School of Pharmacy, Universiti Sains Malaysia. (b) College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia. (c) Department of Pharmacy, Medical school in Thamar University , Republic of Yemen
J Clin Diagn Res, 2013 Dec;7(12):2739-43.
PMID: 24551627 DOI: 10.7860/JCDR/2013/6261.3748

Abstract

The Liquid Chromatography Tandem Mass Spectrometry (LC-MS-MS) for determination simvastatin in human plasma has been developed after extraction by by ethyl acetate and hexane (90/10%, v/v) using lovastatin as internal standard.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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