Affiliations 

  • 1 School of Biosciences, Faculty of Health and Medicine Sciences, Taylor's University, Subang Jaya, Malaysia
  • 2 National Centre for Infectious Diseases, Singapore, Singapore
  • 3 National Centre for Infectious Diseases, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore
  • 4 National Centre for Infectious Diseases, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; Department of Medicine, The Doherty Institute, University of Melbourne, Melbourne, Australia. Electronic address: andrewcc.teo@ntu.edu.sg
Trends Microbiol, 2024 May 14.
PMID: 38749772 DOI: 10.1016/j.tim.2024.04.011

Abstract

Dengue is a mosquito-borne viral disease which causes significant morbidity and mortality each year. Previous research has proposed several mechanisms of pathogenicity that mainly involve the dengue virus and host humoral immunity. However, innate immune cells, such as neutrophils, may also play an important role in dengue, albeit a much less defined role. In this review, we discuss the emerging roles of neutrophils in dengue and their involvement in pathologies associated with severe dengue. We also describe the potential use of several neutrophil proteins as biomarkers for severe dengue. These studies suggest that neutrophils are important players in dengue, and a better understanding of neutrophil-dengue biology is urgently needed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.