Affiliations 

  • 1 Department of Medicine, Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India
  • 2 Department of Pharmacology, School of Medical & Allied Sciences, G.D. Goenka University, Gurugram, India
  • 3 NIMS Institute of Pharmacy, NIMS University, Jaipur, India
  • 4 Department of Pharmacology, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur, 302023, India
  • 5 Department of Pharmacology, Jeffrey Cheah School of Medicine & Health Sciences, MONASH University, Malaysia
  • 6 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, Rajasthan, India-302017
  • 7 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan 302017, India
Curr Cardiol Rev, 2024 Jul 03.
PMID: 38963101 DOI: 10.2174/011573403X290326240703100925

Abstract

BACKGROUND: Brucellosis is a public health concern that affects multiple organs. However, cardiovascular problems arise infrequently, affecting fewer than 2% of cases, typically presenting as endocarditis.

CASE PRESENTATION: A 50-year male was admitted with low-grade fever, night sweats, weight loss (13 kg), malaise, and generalized weakness for the past 6 months. On clinical examination, he was febrile with 39.0°C, an average heart rate of 54 bpm, and 100/40 mmHg blood pressure. On cardiovascular examination, S1 and S2 were soft with pan systolic murmur present in the mitral area, and the early diastolic murmur was present in the left third intercostal space. Electrocardiography was suggestive of third-degree heart block with AV dissociation. Transthoracic echocardiography showed mobile vegetations attached to multiple valves- an aortic valve (18.2x11.9mm) and a mitral valve (2.9x7.5mm) with perivalvular abscess. He was given oral doxycycline (100mg B.D.) and rifampicin (600mg/day); the patient responded, but the AV block did not resolve.

CONCLUSION: This report has drawn attention to multivalvular involvement and cardiac rhythm abnormalities in Brucellosis (in this case, A.V. dissociation was present) because early diagnosis and treatment can cause a significant decrease in morbidity as well as mortality by appropriate treatment.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.