Enhancing orthodontic treatment control with fish scale-derived hydroxyapatite nanoparticles: Insights from an animal model study

Mohammed-Salih HS 1 , Ghazi A 2 , Mahmood RI 3 , Al-Qazzaz HH 4 , Supian FL 5 , Al-Obaidi JR 6 Show all authors , Jabir M 7

Affiliations 

  • 1 Department of Orthodontics, College of Dentistry, University of Baghdad, Baghdad 10047, Iraq
  • 2 P.O.P. Department, College of Dentistry, Mustansiriya University, Baghdad 10052, Iraq
  • 3 Department of Biomedical Engineering, College of Engineering, Al-Nahrain University, Jadriya, Baghdad, Iraq
  • 4 Department of Pathology, Teaching Laboratories, Al Yarmouk Teaching Hospital, Baghdad 10017, Iraq
  • 5 Department of Physics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900, Tanjong Malim, Perak, Malaysia
  • 6 Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900, Tanjong Malim, Perak, Malaysia
  • 7 Department of Applied Sciences -University of Technology, Baghdad 10066, Iraq
Saudi Dent J, 2024 Aug;36(8):1128-1134.
PMID: 39176163 DOI: 10.1016/j.sdentj.2024.06.007

Abstract

OBJECTIVES: This study investigates the impact of injected fish-scale-derived hydroxyapatite nanoparticles (FsHA-NPs) on orthodontic tooth movement (OTM) and the width of the periodontal ligament (PDL) space.

MATERIALS AND METHODS: Twenty-six Wistar rats underwent mesial orthodontic traction with a force of 50 g for 21 days. Following the application of the orthodontic appliance, the rats were randomly divided into two groups: a control group, which received a 0.3 µg saline injection, and the experimental FsHA group, which received 100 mg/0.3 ml of FsHA-NPs after thorough characterisation. Injections were administered immediately after appliance application and repeated at 7 and 14 days. Statistical analysis was conducted with a significance level of P ≤ 0.05.

RESULT: The experimental group exhibited a significant reduction in OTM at 7-, 14-, and 21-day post-force application. Additionally, a reduction in PDL width was observed in the mesiocervical and disto-apical regions of the mesial and distal roots of the first molar.

CONCLUSION: FsHA-NPs derived from biowaste fish scales exhibit promising potential as biomaterials for enhancing control over OTM. This study underscores the viability, accessibility, and safety of FsHA-NPs as a locally injectable material for orthodontic applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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