The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives

Mohamed W 1 , Eltantawi MA 2 , Agarwal V 3 , Bandres-Ciga S 4 , Makarious MB 4 , Mecheri Y 5 Show all authors , Zewde YZ 6 , Kamel WA 7 , Al-Mubarak B 8 , Alzoubi KH 9 , Kissani N 10 , Alghamdi BS 11 , Sassi SB 12 , AA-PD-GC

Affiliations 

  • 1 Basic Medical Science Department, Kulliyyah of Medicine, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia
  • 2 Department of Neurology, Faculty of Medicine, Delta University for Science and Technology, 11152 Gamasa, Egypt
  • 3 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA
  • 4 Centre for Alzheimer's Disease and Related Dementias (CARD), National Institute on Ageing (NIA), National Institutes of Health (NIH), Bethesda, MD 20892, USA
  • 5 Neurology Department, Dr Benbadis University Hospital, 25000 Constantine, Algeria
  • 6 Department of Neurology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
  • 7 Department of Neurology, Beni-Suef University, 62511 Beni-Suef, Egypt
  • 8 King Faisal Specialist Hospital and Research Center, 11564 Riyadh, Saudi Arabia
  • 9 Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, 27272 Sharjah, United Arab Emirates
  • 10 Department of Neurology, Marrakech Faculty of Medicine and Pharmacy, University Hospital Mohamed VI, 5244 Marrakech, Morocco
  • 11 Neuroscience and Geroscience Research Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia
  • 12 National Institute Mongi Ben Hmida of Neurology, 1007 Tunis, Tunisia
J Integr Neurosci, 2024 Aug 19;23(8):152.
PMID: 39207075 DOI: 10.31083/j.jin2308152

Abstract

Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications