Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis

Lim SYM 1 , Lim W 2 , Peter AP 3 , Pan Y 1 , Alshagga M 1 , Alshawsh MA 4

Affiliations 

  • 1 Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia
  • 2 Faculty of Engineering, Computing and Science, Swinburne University of Technology, Kuching, Sarawak, Malaysia
  • 3 School of Engineering, Faculty of Innovation and Technology, Taylor's University Lakeside Campus, Subang Jaya, Malaysia
  • 4 Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
J Appl Toxicol, 2024 Oct 04.
PMID: 39367649 DOI: 10.1002/jat.4707

Abstract

The CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. elegans CYP33 suggests its functions are similar to human CYP33, indicating conserved roles in metabolism and disease. This review examines C. elegans CYP33 enzymes, especially CYP-33E1 and CYP-33E2, and their human homologues, focusing on their roles in eicosanoid biosynthesis, xenobiotic metabolism, nanotoxicity and spermatogenesis. Understanding these enzymes enhances insights into cytochrome P450 biology, metabolism and cyp-associated diseases.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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