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Electrospinning of Poly-3-Hydroxybutyrate Fibers Loaded with Chlorophyll for Antibacterial Purposes

Tyubaeva PM 1 , Varyan IA 1 , Romanov RR 2 , Merzlikin VA 1 , Gruznova OA 3 , Gruznov DV 4 Show all authors , Popov NI 5 , Shcherbakova GS 5 , Shuteeva EN 5 , Chesnokova IP 3 , Lobanov AV 6 , Olkhov AA 1

Affiliations 

  • 1 Department of Physical Chemistry of Synthetic and Natural Polymer Compositions, Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina St., 119334 Moscow, Russia
  • 2 Academic Department of Innovational Materials and Technologies Chemistry, Plekhanov Russian University of Economics, 36 Stremyanny Per., 117997 Moscow, Russia
  • 3 Laboratory of Liquid-Phase Oxidation, Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 4 Kosygina Street, 119334 Moscow, Russia
  • 4 Laboratory of Veterinary Sanitation and Environmental Safety in Beekeeping, All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology-Branch of Federal State Budget Scientific Institution "Federal Scientific Center-K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences", 5 Zvenigorodskoye Highway, 123022 Moscow, Russia
  • 5 Laboratory of Veterinary Sanitation, All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology-Branch of Federal State Budget Scientific Institution "Federal Scientific Center-K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute of Experimental Veterinary Medicine, Russian Academy of Sciences", 5 Zvenigorodskoye Highway, 123022 Moscow, Russia
  • 6 Department of General Chemistry, Moscow Pedagogical State University, 1/1 Malaya Pirogovskaya Street, 119435 Moscow, Russia
Polymers (Basel), 2024 Nov 20;16(22).
PMID: 39599313 DOI: 10.3390/polym16223221

Abstract

This work is devoted to the creation of biocompatible fibrous materials with a high antimicrobial effect based on poly-3-hydroxybutyrate (PHB) and chlorophyll (Chl). The data obtained show the possibility of obtaining fibrous materials from PHB and Chl by electrospinning methods. The obtained electrospun matrices were investigated by the SEM, DSC and FTIR methods. Various key properties of the matrices were evaluated, including hydrophilicity and mechanical strength, as well as photodynamic and light-dependent antimicrobial effects against the conditionally pathogenic microorganism Staphylococcus aureus. The results demonstrate a significant improvement in electrospinning properties for a concentration of 0.5% Chl and a reduction in fiber formation defects, as well as an increase in the strength of nonwovens. It was found that the antimicrobial potential of Chl-PHB (with concentrations of Chl of 1.25 and 1.5%) is higher than that of Chl in free form. It was also determined that irradiation increases the inhibitory effect of Chl, both in free form and in the form of a complex with a polymer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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