Comparative Assessment of Agreement in Uniformity Analyses across Quality Control Software Platforms

Objective  In nuclear medicine, quality control (QC) activities adhere to international standards, yet their complexity can pose challenges. Gamma camera manufacturers have introduced integrated QC software, offering instantaneous results. However, the agreement of these automated processes with established protocols remains uncertain. This study aims to clarify this uncertainty by comparatively analyzing uniformity from various software solutions for a dual-head gamma camera. Methods  The study utilized integrated QC analysis software and three free QC analysis tools (IAEA-NMQC Toolkit, NM Toolkit, and Fiji) for uniformity analyses. Following the National Electrical Manufacturers Association standards, NEMA Standards Publication NU 1-2018, the intrinsic uniformity test was performed on a GE Discovery NM/CT 670 Pro system. Ten uniformity QC images underwent analysis with both integrated QC software and alternative software. Data agreements were tested using the Blant-Altman regression-based analysis. Results  Significant differences were observed in integral and differential uniformities ( p