Is stone composition analysis between two-stage stone surgery essential?

Huang Z 1 , Zhong J 2 , Zhang G 2 , Ann CC 3 , Ai G 2 , Zeng G 2 Show all authors , Zhu W 4

Affiliations 

  • 1 Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 510230; Guangzhou Institute of Urology; Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China
  • 2 Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 510230; Guangzhou Institute of Urology
  • 3 Urology Unit, Department of Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia, 50603
  • 4 Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 510230; Guangzhou Institute of Urology. Electronic address: doczw1989@126.com
Urology, 2025 Mar 03.
PMID: 40043958 DOI: 10.1016/j.urology.2025.02.042

Abstract

OBJECTIVE: To investigate the changes of the stone composition between two stages of stone surgery.

METHODS: We prospectively enrolled 600 patients from a single medical center between October 2015 and June 2021. The stones were analyzed using Fourier transformation infrared spectrometer (Bruker, Karlsruhe, Germany). Calculi were classified based on their primary component. Ultimately, a total of 520 patients met the criteria and entered the final analyses. The stone composition between the two stages of surgery was compared.

RESULTS: Of the 520 patients, 277 were male and the mean age was 52.9±12.8. The average time delay between two stone analyses was approximately 33.2 days. One hundred and eighty-six cases (35.8%) had different compositions on the second-stage analyses, with a total of 67 (36.0%) cases transitioning to a totally different type of stones. Forty-one (16.5%) cases initially identified as infection stones changed to non-infection stones and 35 (12.9%) cases transformed from non-infection stones to infected stones.

CONCLUSIONS: Up to 35.8% of stones underwent changes during the second stone composition analysis, and up to 36.0% of these altered stones had transformed to a totally different type. Conducting stone composition analysis between two stages of surgery is essential for the development of follow-up treatment and drug prevention plans.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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