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In vitro immunogenic and immunostimulatory effects of zwitterionized 23-valent pneumococcal polysaccharide vaccine compared with nonzwitterionized vaccine

Abdulamir AS 1 , Hafidh RR 2 , Abubaker F 3

Affiliations 

  • 1 Institute of Bioscience, University Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia ; Microbiology Department, College of Medicine, Alnahrain University, Baghdad, Iraq
  • 2 Institute of Bioscience, University Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia ; Microbiology Department, College of Medicine, Baghdad University, Baghdad, Iraq
  • 3 Institute of Bioscience, University Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
Curr Ther Res Clin Exp, 2010 Feb;71(1):60-77.
PMID: 24683251 DOI: 10.1016/j.curtheres.2010.02.004

Abstract

It was hypothesized that the observed slight immunostimulatory effect of the 23-valent pneumococcal polysaccharide (pneumo-23) vaccine might be due to the presence of low levels of zwitterionic motifs. Therefore, it was hypothesized further that introducing zwitterionic motifs experimentally into polysaccharides of pneumo-23 vaccine might render it an effective immunostimulatory agent.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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