Rapid label-free profiling of oral cancer biomarker proteins using nano-UPLC-Q-TOF ion mobility mass spectrometry

Nassar AF 1 , Williams BJ 2 , Yaworksy DC 2 , Patel V 3 , Rusling JF 4

Affiliations 

  • 1 Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA
  • 2 Waters Corporation, Milford, MA, USA
  • 3 Cancer Research Initiatives Foundation (CARF), Sime Darby Medical Centre, Subang Jaya, Malaysia
  • 4 Department of Chemistry, University of Connecticut, Storrs, CT, USA
Proteomics Clin Appl, 2016 Mar;10(3):280-9.
PMID: 26684082 DOI: 10.1002/prca.201500025

Abstract

It has become quite clear that single cancer biomarkers cannot in general provide high sensitivity and specificity for reliable clinical cancer diagnostics. This paper explores the feasibility of rapid detection of multiple biomarker proteins in model oral cancer samples using label-free protein relative quantitation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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