A 19-Gene expression signature as a predictor of survival in colorectal cancer

Abdul Aziz NA 1 , Mokhtar NM 2 , Harun R 1 , Mollah MM 1 , Mohamed Rose I 3 , Sagap I 4 Show all authors , Mohd Tamil A 5 , Wan Ngah WZ 1 , Jamal R 6

Affiliations 

  • 1 UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia (UKM), Cheras, Kuala Lumpur, Malaysia
  • 2 Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia. norfilza@ppukm.ukm.edu.my
  • 3 Histopathology Unit, Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • 4 Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • 5 Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 6 UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia (UKM), Cheras, Kuala Lumpur, Malaysia. rahmanj@ppukm.ukm.edu.my
BMC Med Genomics, 2016;9(1):58.
PMID: 27609023 DOI: 10.1186/s12920-016-0218-1

Abstract

Histopathological assessment has a low potential to predict clinical outcome in patients with the same stage of colorectal cancer. More specific and sensitive biomarkers to determine patients' survival are needed. We aimed to determine gene expression signatures as reliable prognostic marker that could predict survival of colorectal cancer patients with Dukes' B and C.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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