Genome sequencing-assisted identification and the first functional validation of N-acyl-homoserine-lactone synthases from the Sphingomonadaceae family

Gan HM 1 , Dailey LK 2 , Halliday N 3 , Williams P 3 , Hudson AO 2 , Savka MA 2

Affiliations 

  • 1 School of Science, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia; Genomics Facility, Tropical Medicine Biology Platform, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia
  • 2 Thomas H. Gosnell School of School of Life Sciences, Rochester Institute of Technology , Rochester , NY , USA
  • 3 School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham , Nottingham , UK
PeerJ, 2016;4:e2332.
PMID: 27635318 DOI: 10.7717/peerj.2332

Abstract

Members of the genus Novosphingobium have been isolated from a variety of environmental niches. Although genomics analyses have suggested the presence of genes associated with quorum sensing signal production e.g., the N-acyl-homoserine lactone (AHL) synthase (luxI) homologs in various Novosphingobium species, to date, no luxI homologs have been experimentally validated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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