Affiliations 

  • 1 College of Applied Medical Science, Prince Sattam Bin Abdul-Aziz University, Wadi Ad Dawaser, Saudi Arabia
  • 2 School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia
  • 3 Department of Physiology, Aras Windle, University College Cork, Cork, Ireland
Auton Autacoid Pharmacol, 2017 Jan;37(1):13-18.
PMID: 28332265 DOI: 10.1111/aap.12053

Abstract

Altered renal adrenergic responses have been recognized as pathophysiological responses to high salt intake. This study aims to investigate the influence of 6 weeks of high salt diet on α1A -adrenoceptor regulation of renal tubular antinatriuretic and antidiuretic response in normal Wistar Kyoto rats. To achieve the above objective, antinatriuretic and antidiuretic response to phenylephrine was measured in the absence and presence of 5-methylurapidil (5-MeU) using the inulin clearance method. Systemic mean arterial blood pressure and renal haemodynamics were also measured simultaneously. Six weeks of high salt intake in Wistar-Kyoto (WKY) rats did not bring any significant increase in mean arterial blood pressure. WKY rat on high salt diet (WKYHNa) showed an exaggerated increase in absolute and fractional sodium excretion. There was a significant involvement of α1A -adrenoceptor in carrying out renal tubular antinatriuretic and antidiuretic response in Wistar Kyoto rats on normal sodium diet (WKYNNa). However, α1A -adrenoceptor played a minimal role in handling the tubular reabsorptive response in WKY rats on high salt diet.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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