Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Patel RP 1 , Jacob J 2 , Sedeeq M 2 , Ming LC 3 , Wanandy T 4 , Zaidi STR 2 Show all authors , Peterson GM 2

Affiliations 

  • 1 Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. Electronic address: rahul.patel@utas.edu.au
  • 2 Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
  • 3 Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia; School of Pharmacy, KPJ Healthcare University College, Nilai, Malaysia
  • 4 Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia; Department of Pharmacy and Jack Jumper Allergy Program, Royal Hobart Hospital, Hobart, Tasmania, Australia
Clin Ther, 2018 04;40(4):664-667.
PMID: 29496321 DOI: 10.1016/j.clinthera.2018.02.009

Abstract

PURPOSE: The aim was to investigate the stability of cefazolin in elastomeric infusion devices.

METHODS: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.

FINDINGS: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.

IMPLICATIONS: These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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