OBJECTIVE: The main aim of this study was to examine whether neuroticism mediates the association between loneliness and cognitive function in older adults.
METHODS: This study involved 2322 representative community residents aged 60-92 years in Peninsular Malaysia. Cognition was measured by Mini-Mental State Examination (MMSE), loneliness was assessed by three-item loneliness scale, and neuroticism was assessed by the Short-Form Revised Eysenck Personality Questionnaire. Hierarchical multiple linear regression and Sobel tests were used for mediation analyses.
RESULTS: Both loneliness (β = -0.04, P = 0.03) and neuroticism (β = -0.07, P < 0.001) were negatively and significantly associated with cognitive function, and most importantly, neuroticism mediated the association between loneliness and cognition (from β = -0.04, P = 0.03 to β = -0.03, P = 0.10).
CONCLUSION: Neuroticism may be the potential mechanism underlying the relationship between loneliness and cognitive function in older persons.
* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.