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Prediction and prevention of early-onset pre-eclampsia: impact of aspirin after first-trimester screening

Park F 1 , Russo K 1 , Williams P 1 , Pelosi M 2 , Puddephatt R 2 , Walter M 2 Show all authors , Leung C 1 , Saaid R 3 , Rawashdeh H 2 , Ogle R 2 , Hyett J 1

Affiliations 

  • 1 Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
  • 2 RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, NSW, Australia
  • 3 RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, NSW, Australia; Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur, Malaysia
Ultrasound Obstet Gynecol, 2015 Oct;46(4):419-23.
PMID: 25678383 DOI: 10.1002/uog.14819

Abstract

OBJECTIVE: To examine the effect of a combination of screening and treatment with low-dose aspirin on the prevalence of early-onset pre-eclampsia (PE).
METHODS: This was a retrospective analysis of two consecutive cohorts of women screened for early PE. The first cohort was observed to determine whether algorithms developed to screen for PE at 11 to 13 + 6 weeks' gestation could be applied to our population. High-risk women in the second cohort were advised on their risk and offered aspirin (150 mg at night), with treatment starting immediately after screening. The prevalence of early PE and the proportion of women with PE delivering at 34-37 weeks' gestation were compared between the cohorts.
RESULTS: In the observational and interventional cohorts, 3066 and 2717 women, respectively, were screened. There were 12 (0.4%) cases of early PE in the observational cohort and one (0.04%) in the interventional cohort (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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