Glioblastoma multiforme (GBM) is one of the most common primary brain tumours
in adults, accounting for almost 65% of all cases. Among solid tumours, GBM is characterised by
strong angiogenesis, including the highest degree of vascular proliferation and endothelial cell
hyperplasia. Despite numerous improvements in existing treatment approaches, the prognosis
of GBM patients remains poor, with a mean survival of only 14.6 months. Growing evidence has
shown significant overexpression of the ephrin type-A receptor 2 (EphA2) receptor in various
malignancies, including GBM, as well as a correlation to poor prognoses. It is believed that
EphA2 receptors play important roles in mediating GBM tumourigenesis, including invasion,
metastasis, and angiogenesis. Despite the clinical and pathological importance of tumourassociated vasculature, the underlying mechanism involving EphA2 is poorly known. Here,
we have summarised the current knowledge in the field regarding EphA2 receptors’ roles in the
angiogenesis of GBM.