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Effect of surgical intraocular pressure lowering on retinal structures - nerve fibre layer, foveal avascular zone, peripapillary and macular vessel density: 1 year results

Ch'ng TW 1 , Gillmann K 1 , Hoskens K 1 , Rao HL 2 , Mermoud A 1 , Mansouri K 3

Affiliations 

  • 1 Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland
  • 2 Narayana Nethralaya, Bangalore, India
  • 3 Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland. kwmansouri@gmail.com
Eye (Lond), 2020 03;34(3):562-571.
PMID: 31409906 DOI: 10.1038/s41433-019-0560-6

Abstract

OBJECTIVES: To determine the effect of surgical intraocular pressure (IOP) lowering on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT-A).

METHODS: This was a prospective observational study performed at the Glaucoma Research Centre, Montchoisi Clinic, Lausanne. In total 40 eyes with open-angle glaucoma were included. OCT-A scans were performed before glaucoma surgery, and at 1-month, 3-month, 6-month, and 12-month post-operatively. AngioVue AngioAnalytic (Optovue Inc, Fremont, CA) software was used to analyse the RNFL, FAZ, peripapillary and macular VD. Changes were analysed using analysis of variance (ANOVA) models.

RESULTS: Mean IOP dropped from 19.4 (±7.0) mmHg pre-surgery and stabilized at 13.0 (±3.1) mmHg at 12 months (p 

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