Performance of Simple Fibrosis Scores in Nonobese Patients With Nonalcoholic Fatty Liver Disease

Fu C 1 , Wai JW 1 , Nik Mustapha NR 2 , Irles M 3 , Wong GL 4 , Mahadeva S 5 Show all authors , Shili S 3 , Chan AW 6 , Merrouche W 3 , Chan HL 4 , Foucher J 3 , Le Bail B 7 , Wong VW 4 , Chan WK 8 , de Lédinghen V 9

Affiliations 

  • 1 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
  • 2 Department of Pathology, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia
  • 3 Centre d'Investigation de la Fibrose Hépatique, Bordeaux University Hospital, Pessac, France
  • 4 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong; State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong
  • 5 Department of Medicine, Gastroenterology and Hepatology Unit, University of Malaya, Kuala Lumpur, Malaysia
  • 6 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong
  • 7 Pathology Unit, Hôpital Pellegrin, Bordeaux University Hospital, Pessac, France; INSERM U1053, Bordeaux University, Bordeaux, France
  • 8 Department of Medicine, Gastroenterology and Hepatology Unit, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: wahkheong2003@hotmail.com
  • 9 Centre d'Investigation de la Fibrose Hépatique, Bordeaux University Hospital, Pessac, France; INSERM U1053, Bordeaux University, Bordeaux, France. Electronic address: victor.deledinghen@chu-bordeaux.fr
Clin Gastroenterol Hepatol, 2020 11;18(12):2843-2845.e2.
PMID: 31574313 DOI: 10.1016/j.cgh.2019.09.027

Abstract

Because only a minority of patients with nonalcoholic fatty liver disease (NAFLD) have advanced fibrosis and would eventually develop liver-related complications, current guidelines recommend initial assessment with noninvasive tests of fibrosis.1-3 Most previous studies focused on overweight and obese patients. Despite a strong association between obesity and NAFLD, 3%-30% of people with relatively normal body mass index (BMI) may still have NAFLD.4,5 Hence, this study aims to evaluate the performance of the common noninvasive tests in non-obese (BMI <25 kg/m2) and obese (BMI ≥25 kg/m2) NAFLD patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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