Affiliations 

  • 1 International Islamic University Malaysia, Kulliyyah of Medicine, Department of Pathology and Laboratory Medicine, Malaysia. noleata@iium.edu.my
Malays J Pathol, 2016 Apr;38(1):11-8.
PMID: 27126659 MyJurnal

Abstract

Synovial sarcoma (SS) is a rare cancer and accounts for 5-10% of adult soft tissue sarcomas. Making an accurate diagnosis is difficult due to the overlapping histological features of SS with other types of sarcomas and the non-specific immunohistochemistry profile findings. Molecular testing is thus considered necessary to confirm the diagnosis since more than 90% of SS cases carry the transcript of t(X;18)(p11.2;q11.2). The purpose of this study is to diagnose SS at molecular level by testing for t(X;18) fusion-transcript expression through One-step reverse transcriptase real-time Polymerase Chain Reaction (PCR).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.