Affiliations 

  • 1 Research and Development Department, Davos Life Science, Singapore, Singapore, weiling.teo@davoslife.com
  • 2 School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
  • 3 National Skin Centre, Singapore, Singapore
  • 4 Research and Development Department, KL-Kepong Oleomas Sdn Bhd (KLK-Oleo), Selangor, Malaysia
  • 5 Research and Development Department, Davos Life Science, Singapore, Singapore
Dermatology, 2021;237(4):553-564.
PMID: 33070130 DOI: 10.1159/000510653

Abstract

BACKGROUND: Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities.

SUMMARY: This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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