Prader-Willi Syndrome (PWS) is a genetically determined neurodevelopmental disorder
occurring in 1 in 15,000 births. PWS is a rare case in Malaysia and a successful approach to its
management has not been well reported here. We present a case of a 13-year-old boy with
Prader-Willi Syndrome with prominent behavioural disturbances characterised by temper
tantrums, compulsive food intake, stubbornness, stealing and impulsivity further complicated by
underlying morbid obesity, poorly controlled type 2 diabetes mellitus, hypertension,
dyslipidaemia, obstructive sleep apnoea syndrome and intellectual disability. Multidisciplinary
approach involving child and adolescent psychiatrist, occupational therapist, counsellor, family
therapist, endocrinologist and dietician has shown to improve the patient’s weight, glucose and
blood pressure control and most importantly the behavioural disturbances