Can the complete blood count be used as a reliable screening tool for obstructive sleep apnea?

Cummins E 1 , Waseem R 1 , Piyasena D 1 , Wang CY 2 , Suen C 1 , Ryan C 3 Show all authors , Wong J 1 , Kryger M 4 , Chung F 5

Affiliations 

  • 1 Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
  • 2 University of Malaya, Kuala Lumpur, Malaysia
  • 3 Centre of Sleep Health and Research, Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
  • 4 Yale School of Medicine, New Haven, CT, USA
  • 5 Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. frances.chung@uhn.ca
Sleep Breath, 2021 Jun 29.
PMID: 34185230 DOI: 10.1007/s11325-021-02383-3

Abstract

PURPOSE: Since hypoxia increases erythropoietin production and inflammation, the complete blood count (CBC) has been proposed as an inexpensive alternative for obstructive sleep apnea (OSA) screening. The objective of this study was to determine whether or not intermittent hypoxia and OSA severity, as measured by the mean oxygen saturation (SpO2) and apnea-hypopnea index (AHI), affect parameters measured by the CBC.

METHODS: This retrospective study included a total of 941 surgical patients who had a pre-operative home sleep study. The pre-operative CBC was extracted from the electronic patient records. Patients were stratified according to their AHI scores, into mild (AHI ≥ 5 - 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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