Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2

Mbenza NM 1 , Nasarudin N 1 , Vadakkedath PG 1 , Patel K 1 , Ismail AZ 1 , Hanif M 1 Show all authors , Wright LJ 1 , Sarojini V 1 , Hartinger CG 1 , Leung IKH 1

Affiliations 

  • 1 School of Chemical Sciences, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand
Chembiochem, 2021 08 03;22(15):2521-2525.
PMID: 34137488 DOI: 10.1002/cbic.202100181

Abstract

Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing molecule-2 (CORM-2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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