Distant recurrence of endometrial cancer more than 10 years after hysterectomy: a case report

Khoo BP 1 , Chew KT 2 , Hing EY 3 , Kampan N 2 , Shafiee MN 2

Affiliations 

  • 1 Department of Obstetrics and Gynaecology, General Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
  • 2 Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
  • 3 Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
Horm Mol Biol Clin Investig, 2021 Aug 10;42(4):429-433.
PMID: 34378876 DOI: 10.1515/hmbci-2021-0025

Abstract

OBJECTIVES: Endometrial cancer is the sixth most common cancer among women and recurrence of after 10 years is extremely rare.

CASE PRESENTATION: We reported a comprehensive review of histopathology, investigations and treatment regarding a woman with distant recurrence of endometrial cancer to rectus abdominis muscle after 23 years from the primary surgery. Previous published literatures of similar case were included into the review analysis. A total of 11 similar cases had been reported. Overall, 9 (81.8%) cases were stage 1 disease and only 2 cases were classified as stage II disease. The majority, 6 (54.5%) cases were endometrial adenocarcinoma. Majority of the cases shared the similarity of low grade endometrial cancer with positive oestrogen receptor immunophynetype.

CONCLUSIONS: Thus, the phenomenon of 'cell dormancy' was hypothesized to explain the mechanism of late recurrence for these cases.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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