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Catalyst-Free Crosslinking Modification of Nata-de-Coco-Based Bacterial Cellulose Nanofibres Using Citric Acid for Biomedical Applications

Salihu R 1 , Ansari MNM 2 , Abd Razak SI 3 , Ahmad Zawawi N 1 , Shahir S 1 , Sani MH 1 Show all authors , Ramlee MH 4 , Wsoo MA 1 , Mohd Yusof AH 5 , Nayan NHM 6 , Gumel AM 7

Affiliations 

  • 1 Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
  • 2 Institute of Power Engineering, Universiti Tenaga Nasional, Kajang 43000, Selangor, Malaysia
  • 3 Bioinspired Device and Tissue Engineering Research Group, Faculty of Engineering, School of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, Skudai 81310, Johor, Malaysia
  • 4 Medical Devices and Technology Centre (MEDiTEC), Institute of Human-Centered Engineering (iHmEn), Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
  • 5 Faculty of Engineering, School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
  • 6 Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, Batu Pahat, Bahru 86400, Johor, Malaysia
  • 7 Department of Microbiology and Biotechnology, Federal University Dutse, PMB 7156 Ibrahim Aliyu Bypass, Dutse 720101, Jigawa State, Nigeria
Polymers (Basel), 2021 Aug 31;13(17).
PMID: 34503006 DOI: 10.3390/polym13172966

Abstract

Bacterial cellulose (BC) has gained attention among researchers in materials science and bio-medicine due to its fascinating properties. However, BC's fibre collapse phenomenon (i.e., its inability to reabsorb water after dehydration) is one of the drawbacks that limit its potential. To overcome this, a catalyst-free thermal crosslinking reaction was employed to modify BC using citric acid (CA) without compromising its biocompatibility. FTIR, XRD, SEM/EDX, TGA, and tensile analysis were carried out to evaluate the properties of the modified BC (MBC). The results confirm the fibre crosslinking phenomenon and the improvement of some properties that could be advantageous for various applications. The modified nanofibre displayed an improved crystallinity and thermal stability with increased water absorption/swelling and tensile modulus. The MBC reported here can be used for wound dressings and tissue scaffolding.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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