Small Molecules as LIM Kinase Inhibitors

Bukhari SNA 1 , Tandiary MA 2 , Al-Sanea MM 1 , Abdelgawad MA 1 , Chee CF 3 , Hussain MA 4

Affiliations 

  • 1 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014. Saudi Arabia
  • 2 Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907. United States
  • 3 Nanotechnology and Catalysis Research Centre, University of Malaya, 50603 Kuala Lumpur. Malaysia
  • 4 Institute of Chemistry, University of Sargodha, Sargodha. Pakistan
Curr Med Chem, 2021 Oct 26.
PMID: 34702151 DOI: 10.2174/0929867328666211026120335

Abstract

LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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