This paper demonstrates the use of Universal Software Radio Peripheral (USRP), together with Raspberry Pi3 B+ (RP3) as the brain (or the decision making engine), to develop a distributed wireless network in which nodes can communicate with other nodes independently and make decision autonomously. In other words, each USRP node (i.e., sensor) is embedded with separate processing units (i.e., RP3), which has not been investigated in the literature, so that each node can make independent decisions in a distributed manner. The proposed testbed in this paper is compared with the traditional distributed testbed, which has been widely used in the literature. In the traditional distributed testbed, there is a single processing unit (i.e., a personal computer) that makes decisions in a centralized manner, and each node (i.e., USRP) is connected to the processing unit via a switch. The single processing unit exchanges control messages with nodes via the switch, while the nodes exchange data packets among themselves using a wireless medium in a distributed manner. The main disadvantage of the traditional testbed is that, despite the network being distributed in nature, decisions are made in a centralized manner. Hence, the response delay of the control message exchange is always neglected. The use of such testbed is mainly due to the limited hardware and monetary cost to acquire a separate processing unit for each node. The experiment in our testbed has shown the increase of end-to-end delay and decrease of packet delivery ratio due to software and hardware delays. The observed multihop transmission is performed using device-to-device (D2D) communication, which has been enabled in 5G. Therefore, nodes can either communicate with other nodes via: (a) a direct communication with the base station at the macrocell, which helps to improve network performance; or (b) D2D that improve spectrum efficiency, whereby traffic is offloaded from macrocell to small cells. Our testbed is the first of its kind in this scale, and it uses RP3 as the distributed decision-making engine incorporated into the USRP/GNU radio platform. This work provides an insight to the development of a 5G network.
In this paper, genomics and precision medicine have witnessed remarkable progress with the advent of high-throughput sequencing technologies and advances in data analytics. However, because of the data's great dimensionality and complexity, the processing and interpretation of large-scale genomic data present major challenges. In order to overcome these difficulties, this research suggests a novel Intelligent Mutation-Based Evolutionary Optimization Algorithm (IMBOA) created particularly for applications in genomics and precision medicine. In the proposed IMBOA, the mutation operator is guided by genome-based information, allowing for the introduction of variants in candidate solutions that are consistent with known biological processes. The algorithm's combination of Differential Evolution with this intelligent mutation mechanism enables effective exploration and exploitation of the solution space. Applying a domain-specific fitness function, the system evaluates potential solutions for each generation based on genomic correctness and fitness. The fitness function directs the search toward ideal solutions that achieve the problem's objectives, while the genome accuracy measure assures that the solutions have physiologically relevant genomic properties. This work demonstrates extensive tests on diverse genomics datasets, including genotype-phenotype association studies and predictive modeling tasks in precision medicine, to verify the accuracy of the proposed approach. The results demonstrate that, in terms of precision, convergence rate, mean error, standard deviation, prediction, and fitness cost of physiologically important genomic biomarkers, the IMBOA consistently outperforms other cutting-edge optimization methods.