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  1. Impact of whey protein on lipid profiles: A systematic review and meta-analysis
    Gataa IS, Abdullah Z, González Cabrera MV, S R, Verma S, Arora I, et al.
    Nutr Metab Cardiovasc Dis, 2025 Jan 06.
    PMID: 39939251 DOI: 10.1016/j.numecd.2025.103858
    AIMS: This research delved into a comprehensive examination and detailed analysis of the effects of whey protein (WP) supplementation on lipid profile in adults.

    DATA SYNTHESIS: Data used in this research was obtained from diverse clinical trials. Thorough searches were carried out on multiple electronic platforms including PubMed, Embase, Web of Science, Scopus, Google Scholar, and the Cochrane Library from their inception until May 2024. Random effects models were assessed and pooled data were determined as weighted mean differences (WMDs) with a 95 % confidence interval (CI).

    RESULTS: Overall, 20 randomized clinical trials (n = 1638 participants) met our inclusion criteria. The current meta-analysis demonstrates a significant reduction in TG (WMD: -12.21 mg/dL; %95CI: -20.16, -4.26; P = 0.003). Pooled analysis of 19 studies on HDL-c indicated a significant increase (WMD: 2.59 mg/dL; %95CI: 1.11, 4.07; P = 0.001).

    CONCLUSIONS: We found that WP intake can improve TG and HDL-c significantly without significant effects on TC, and LDL-c levels. However, future well-designed with long duration RCTs is required on diverse populations to understand better the effects of these natural compounds and their constituents on lipid profile in adults.

  2. The role of rapid molecular diagnostics in managing bloodstream infections: a microbiological insight
    Gupta J, Gataa IS, Sawaran Singh NS, PadmaPriya G, Ray S, Pal A, et al.
    Folia Microbiol (Praha), 2026 Feb;71(1):21-33.
    PMID: 41108514 DOI: 10.1007/s12223-025-01367-0
    Bloodstream infections (BSIs) represent a significant clinical challenge due to their high morbidity and mortality rates, compounded by the increasing prevalence of antimicrobial resistance (AMR). Even though they are regarded as the gold standard, traditional diagnostic techniques like blood cultures frequently have low sensitivity and delayed findings. Rapid molecular diagnostics (RMDs) have completely changed how BSIs are identified and treated. By using cutting-edge methods like next-generation sequencing (NGS), loop-mediated isothermal amplification (LAMP), polymerase chain reaction (PCR), and microarray-based approaches, RMDs allow for the quick, precise, and thorough identification of pathogens and resistance markers straight from blood samples. By drastically cutting down on diagnostic delays, these technologies enable early targeted therapy start, better clinical results, and less need on broad-spectrum antibiotics, which are the primary cause of AMR. Additionally, advancements like NGS improve diagnostic accuracy by offering profound insights into pathogen genomes, virulence factors, and resistance mechanisms. Barriers including high prices, integration difficulties, and the requirement for specialized knowledge prevent them from being widely adopted, despite their transformational potential. Nevertheless, these issues are being addressed by continuous developments in automation and point-of-care (POC) systems, which should make RMDs more affordable and widely available. In order to improve therapeutic accuracy, reduce AMR, and advance infection control techniques, this research emphasizes the crucial role that RMDs play in the management of BSI. In order to improve customized medicine strategies, future initiatives include streamlining diagnostic processes and combining molecular diagnostics with clinical decision support technologies.
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