Rose Oxide is a monoterpene along with cyclic ether used in fragrance to produce rosy notes, in general, there are 4 stereoisomeric structures of the Rose Oxide, which the cis-configured Rose Oxide has a very unique and strong note in perfumery. In this review, several approaches were reported on account of the Rose Oxide applied in perfumery from 1864 to 2019 via quantitative and qualitative approaches.