In orthopaedic clinical applications, creating biocomposite bone substitutes to take the place of autologous bone transplants is still difficult. Studies have demonstrated for decades that poly (lactic-co-glycolic acid) [PLGA], a common polymer, has many benefits that make it a strong contender for bone replacement. These include biodegradability, good mechanical qualities, and the ability to induce new bone production. Although calcium-based materials are frequently used as bone fillers in bone implantation, the efficiency of ceramic materials containing calcium may be hampered by a number of issues, including low microporosity and quick rates of degradation. In order to overcome these obstacles, scientists are investigating ways to improve implant performance by combining PLGA with other materials, especially in terms of encouraging improved connections with nearby bone cells. An overview of the chemical properties of different PLGA-based scaffold composites, as well as the benefits and drawbacks of PLGA-Calcium implants in tissue engineering applications, are the goals of this review. It also highlights the possible advantages and consequences of using PLGA in 3D printing technology to improve bone tissue engineering clinical outcomes.