MyMedR

Fulltext Palm tocotrienol supplementation enhanced bone formation in oestrogen-deficient rats

Soelaiman IN, Ming W, Abu Bakar R, Hashnan NA, Mohd Ali H, Mohamed N, et al.

Int J Endocrinol, 2012;2012:532862.

PMID: 23150728 DOI: 10.1155/2012/532862

Postmenopausal osteoporosis is the commonest cause of osteoporosis. It is associated with increased free radical activity induced by the oestrogen-deficient state. Therefore, supplementation with palm-oil-derived tocotrienols, a potent antioxidant, should be able to prevent this bone loss. Our earlier studies have shown that tocotrienol was able to prevent and even reverse osteoporosis due to various factors, including oestrogen deficiency. In this study we compared the effects of supplementation with palm tocotrienol mixture or calcium on bone biomarkers and bone formation rate in ovariectomised (oestrogen-deficient) female rats. Our results showed that palm tocotrienols significantly increased bone formation in oestrogen-deficient rats, seen by increased double-labeled surface (dLS/Bs), reduced single-labeled surface (sLS/BS), increased mineralizing surface (MS/BS), increased mineral apposition rate (MAR), and an overall increase in bone formation rate (BFR/BS). These effects were not seen in the group supplemented with calcium. However, no significant changes were seen in the serum levels of the bone biomarkers, osteocalcin, and cross-linked C-telopeptide of type I collagen, CTX. In conclusion, palm tocotrienol is more effective than calcium in preventing oestrogen-deficient bone loss. Further studies are needed to determine the potential of tocotrienol as an antiosteoporotic agent.

Fulltext catena-Poly[[triphenyl-tin(IV)]-μ-2-[(3,5-di-tert-butyl-4-hydroxy-benz-yl)sulfan-yl]acetato-κO:O']

Lee SM, Lo KM, Mohd Ali H, Robinson WT

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 7):m808.

PMID: 21582732 DOI: 10.1107/S1600536809023150

The title compound, [Sn(C(6)H(5))(3)(C(17)H(25)O(3)S)](n), comprises two symmetry-independent five-coordinated triphenyl-tin mol-ecules which are linked by carboxyl-ate bridges into a polymeric chain. The Sn(IV) atom is in a distorted trans-C(3)SnO(2) trigonal-bipyramidal geometry. The presence of two bulky tert-butyl groups on the benzene ring prevents any hydrogen-bonding inter-actions involving the hydroxyl substituents.

Fulltext Bis[4-(dimethyl-amino)pyridinium] tetra-bromidobis(4-methyl-phen-yl)stannate(IV)

Lee SM, Lo KM, Mohd Ali H, Robinson WT

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 9):m1040.

PMID: 21577403 DOI: 10.1107/S1600536809030323

In the title compound, (C(7)H(11)N(2))(2)[SnBr(4)(C(7)H(7))(2)], the tetra-bromidobis(4-methyl-phen-yl)stannate(IV) anion possesses a centre of inversion located at the Sn(IV) atom. In the crystal structure, two inversion-related cations are linked to the anion via weak N-H⋯Br hydrogen bonds.

Fulltext Bis[4-(dimethyl-amino)pyridinium] tetra-bromidobis(4-chloro-phen-yl)stannate(IV)-4-bromo-chloro-benzene (1/1)

Lee SM, Lo KM, Mohd Ali H, Robinson WT

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 9):m1039.

PMID: 21577402 DOI: 10.1107/S1600536809030232

In the title compound, (C(7)H(11)N(2))(2)[SnBr(4)(C(6)H(4)Cl)(2)]·C(6)H(4)BrCl, the Sn(IV) atom in the tetra-bromidobis(4-chloro-phen-yl)stannate(IV) anion lies on a centre of inversion. The distances between the 4-(dimethyl-amino)pyridinium N atom and the Br atoms of the anion are 3.450 (2) and 3.452 (2) Å, suggesting weak hydrogen bonding. The 4-bromo-chloro-benzene solvent mol-ecule, which is a bromination by-product from the reaction, is disordered about a twofold rotation axis with approximately equal occupancy.

Fulltext Kelussia odoratissima Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo

Karimian H, Arya A, Fadaeinasab M, Razavi M, Hajrezaei M, Karim Khan A, et al.

Drug Des Devel Ther, 2017;11:337-350.

PMID: 28203057 DOI: 10.2147/DDDT.S121518

BACKGROUND: The aim of this study was to evaluate the anticancer potential of Kelussia odoratissima. Several in vitro and in vivo biological assays were applied to explore the direct effect of an extract and bioactive compound of this plant against breast cancer cells and its possible mechanism of action.

MATERIALS AND METHODS: K. odoratissima methanol extract (KME) was prepared, and MTT assay was used to evaluate the cytotoxicity. To identify the cytotoxic compound, a bioassay-guided investigation was performed on methanol extract. 8-Hydroxy-ar-turmerone was isolated as a bioactive compound. In vivo study was performed in the breast cancer rat model. LA7 cell line was used to induce the breast tumor. Histopathological and expression changes of PCNA, Bcl-2, Bax, p27 and p21 and caspase-3 were examined. The induction of apoptosis was tested using Annexin V-fluorescein isothiocyanate (FITC) assay. To confirm the intrinsic pathway of apoptosis, caspase-7 and caspase-9 assays were utilized. In addition, cell cycle arrest was evaluated.

RESULTS: Our results demonstrated that K. odoratissima has an obvious effect on the arrest of proliferation of cancer cells. It induced apoptosis, transduced the cell death signals, decreased the threshold of mitochondrial membrane potential (MMP), upregulated Bax and downregulated Bcl-2.

CONCLUSION: This study demonstrated that K. odoratissima exhibits antitumor activity against breast cancer cells via cell death and cell cycle arrest.

Fulltext Bis[4-hydr-oxy-N'-(4-meth-oxy-2-oxido-benzyl-idene-κO)benzohydrazidato-κO,N']cadmium(II) dimethyl sulfoxide disolvate

Mohd Lair N, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 5):m541.

PMID: 21583778 DOI: 10.1107/S1600536809013774

The metal atom in the title compound, [Cd(C(15)H(13)N(2)O(4))(2)]·2C(2)H(6)OS, is twice O,N,O'-chelated by two symmetry-related Schiff base ligands to define a trans-N(2)O(4) octa-hedral geometry. Each anion occupies meridional sites of the octa-hedron; the metal atom lies on a special position of site symmetry 2. The dimethyl sulfoxide mol-ecule is a hydrogen-bond acceptor to the -NH- unit, and O-H⋯O hydrogen bonds link mol-ecules into a supra-molecular chain.

Fulltext 5-Meth-oxy-2-[(2-morpholinoeth-yl)-iminio-meth-yl]phenolate

Mohd Lair N, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 5):o1067.

PMID: 21583883 DOI: 10.1107/S1600536809013786

Each of the two independent mol-ecules of the title comound, C(14)H(20)N(2)O(3), exists in the zwitterionic form as the imino N atoms are protonated. The =N-H unit forms an intra-molecular hydrogen bond to the negatively charged O atom, and also a weaker intermolecular N-H⋯O bond, the latter resulting in inversion dimers.

Fulltext Bis{benzyl N'-[(1H-indol-3-yl)methyl-ene]dithio-carbazato-κN',S}copper(II) N,N-dimethyl-formamide disolvate

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 2):m139.

PMID: 21581755 DOI: 10.1107/S1600536808043808

In the structure of [Cu(C(17)H(14)N(3)S(2))(2)]·2C(3)H(7)NO, the Cu atom (site symmetry ) is N,S-chelated by the two deprotonated Schiff-base anions that define a distorted square-planar geometry. An N-H⋯O hydrogen bond links the mononuclear complex to the DMF solvent mol-ecules.

Fulltext Bis{5-methoxy-2-[(2-morpholinoethyl)iminomethyl-κN]phenolato-κO}nickel(II)

Mohd Lair N, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 7):m733.

PMID: 21582675 DOI: 10.1107/S1600536809020790

The asymmetric unit of the crystal structure of the title compound, [Ni(C(14)H(19)N(2)O(3))(2)], contains two independent Ni(II) complex mol-ecules, with the metal atoms each located on a center of inversion. Each metal atom is chelated by two Schiff base anions in a distorted square-planar coordination environment.

Fulltext [N'-(5-Chloro-2-oxidobenzyl-idene-κO)-3-hydr-oxy-2-naphthohydrazidato-κN',O]dimethyl-tin(IV)

Lee SM, Lo KM, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 7):m816.

PMID: 21582739 DOI: 10.1107/S1600536809022259

The Sn(IV) atom in the title compound, [Sn(CH(3))(2)(C(18)H(11)ClN(2)O(3))], shows a trans-C(2)NO(2)Sn trigonal-bipyramidal coordin-ation; the axial O-Sn-O angle is 155.22 (5)°. The tridentate N'-(5-chloro-2-oxidobenzyl-idene)-3-hydr-oxy-2-naphthohydrazidate dianion is stabilized by an intra-molecular O-H⋯N hydrogen bond.

Fulltext Chlorido{4-chloro-2-[(2-morpholinoeth-yl)imino-meth-yl]phenolato-κN,N',O}copper(II)

Ikmal Hisham NA, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 8):m870.

PMID: 21583336 DOI: 10.1107/S1600536809025215

The Cu(II) atom in the title compound, [Cu(C(13)H(16)ClN(2)O(2))Cl], exists in a distorted square-planar coordination environment as the deprotonated Schiff base chelates to the Cu(II) atom through three atom sites. In the crystal structure, adjacent mol-ecules are linked by a Cu⋯Cl [3.011 (1) Å] bridge, generating a linear chain running along the b axis of the ortho-rhom-bic unit cell.

Fulltext Tetra-μ(2)-acetato-bis-{μ(2)-5-meth-oxy-2-[(2-morpholinoeth-yl)iminio-meth-yl]phenolato}tricadmium(II)

Mohd Lair N, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2009;65(Pt 8):m1011.

PMID: 21583308 DOI: 10.1107/S1600536809029171

The central Cd(II) atom in the trinuclear title compound, [Cd(3)(C(14)H(19)N(2)O(3))(2)(CH(3)COO)(4)], lies on a center of inversion and is bonded to the O atoms of four acetate groups as well as to the phenolate O atoms of the mono-deprotonated Schiff base ligands in a distorted all-trans octa-hedral geometry. Two of the acetate groups function in a μ(2)-bridging mode, while the other two each chelate to the terminal Cd(II) atom and simultaneously bind to the central metal atom in a κ(3)-bonding mode. The Schiff base anions N,O-chelate to the terminal metal atoms. The morpholine ring assumes a chair conformation.

Fulltext Bis[benzyl N'-(1H-indol-3-ylmethyl-ene)hydrazinecarbodithio-ato-κN',S]nickel(II) N,N-dimethyl-formamide disolvate

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008 Nov 26;64(Pt 12):m1615.

PMID: 21581208 DOI: 10.1107/S1600536808038580

In the title compound, [Ni(C(17)H(14)N(3)S(2))(2)]·2C(3)H(7)NO, the Ni atom (site symmetry ) is N,S-chelated by two deprotonated Schiff base anions in a distorted square-planar geometry. The dihedral angle between the aromatic ring planes within the ligand is 86.37 (13)°. In the crystal structure, an N-H⋯O hydrogen bond links the complex to the dimethyl-formamide solvent mol-ecule.

Fulltext Benzyl N'-(4,6-dimeth-oxy-2-methyl-3-phenyl-1H-indol-7-ylmethyl-ene)hydrazinecarbodithio-ate

Khaldei H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 12):o2442.

PMID: 21581410 DOI: 10.1107/S1600536808038592

The asymmetric unit of the title compound, C(26)H(25)N(3)O(2)S(2), contains two independent mol-ecules, which are linked by a pair of N-H⋯S hydrogen bonds, forming a dimer.

Fulltext Benzyl N'-(1H-indol-2-ylmethyl-ene)hydrazinecarbodithio-ate ethanol hemisolvate

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 12):o2445.

PMID: 21581413 DOI: 10.1107/S1600536808038609

In the crystal of the title compound, C(17)H(15)N(3)S(2)·0.5C(2)H(6)O, the mol-ecules are linked by a pair of N-H(aliphatic)⋯S hydrogen bonds across a center of inversion, forming a dimer. The ethanol solvent mol-ecule, which is statistically disordered about a crystallographic twofold rotation axis, accepts an N-H(aromatic)⋯O hydrogen bond; the hydr-oxy group of the solvent mol-ecule is not engaged in hydrogen bonding.

Fulltext Benzyl N'-(1-methyl-1H-indol-2-ylmethyl-ene)hydrazinecarbodithio-ate

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008 Nov 26;64(Pt 12):o2430.

PMID: 21581398 DOI: 10.1107/S1600536808038579

In the title compound, C(18)H(17)N(3)S(2), the dihedral angle between the planes of the aromatic ring systems is 83.63 (16)°. In the crystal structure, inversion dimers occur, linked by pairs of N-H⋯S hydrogen bonds.

Fulltext N'-(5-Bromo-1H-indol-3-ylmethyl-idene)-3,4,5-trihydroxy-benzohydrazide

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;64(Pt 11):o2108.

PMID: 21580972 DOI: 10.1107/S1600536808031991

The two aromatic parts of the title mol-ecule, C(16)H(12)BrN(3)O(4), are connected through a conjugated -CH=N-NH-C(O)- fragment to furnish an almost planar mol-ecule. Adjacent mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds into a three-dimensional network. An intramolecular O-H⋯O link also occurs.

Fulltext Benzyl N'-(1H-indol-3-ylmethyl-idene)-hydrazinecarbodithio-ate

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008 Oct 11;64(Pt 11):o2107.

PMID: 21580971 DOI: 10.1107/S160053680803198X

The C(10)H(8)N(3)S(2) portion of the title mol-ecule, C(17)H(15)N(3)S(3), is nearly planar (r.m.s. deviation 0.05 Å); this unit and the phenyl ring subtend an angle of 114.5 (2)° at the methyl-ene C atom.

Fulltext (E)-4-Hydr-oxy-N'-(2-hydr-oxy-4-methoxy-benzyl-idene)benzohydrazide monohydrate

Mohd Lair N, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;65(Pt 1):o189.

PMID: 21581643 DOI: 10.1107/S1600536808042888

The Schiff base mol-ecule of the title compound, C(15)H(14)N(2)O(4)·H(2)O, adopts a trans configuration with respect to the C=N double bond; the Schiff base itself is almost planar (r.m.s. deviation for all non-H atoms = 0.040 Å). The amido N atom is the hydrogen-bond donor to the water mol-ecule, which is the hydrogen-bond donor to the hydr-oxy groups of two neighboring mol-ecules. One of the hydroxyl groups acts as an intra-molecular and the other as an inter-molecular hydrogen-bond donor.

Fulltext N'-[(5-Chloro-1H-indol-3-yl)methyl-ene]-3,4,5-trihydroxy-benzohydrazide

Khaledi H, Mohd Ali H, Ng SW

Acta Crystallogr Sect E Struct Rep Online, 2008;65(Pt 1):o169.

PMID: 21581625 DOI: 10.1107/S160053680804258X

The two aromatic parts of the title compound, C(16)H(13)ClN(3)O(4), are connected through a conjugated -CH=N-NH-C(O)- fragment, giving an almost planar mol-ecule (r.m.s. deviation 0.08 Å). In the crystal structure, adjacent mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds into a three-dimensional network.

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