A sustainable power source to meet the needs of energy requirement is very much essential in modern society as the conventional sources are depleting. Bioenergy, hydropower, solar, and wind are some of the well-established renewable energy sources that help to attain the need for energy at mega to gigawatts power scale. Nanogenerators based on nano energy are the growing technology that facilitate self-powered systems, sensors, and flexible and portable electronics in the booming era of IoT (Internet of Things). The nanogenerators can harvest small-scale energy from the ambient nature and surroundings for efficient utilization. The nanogenerators were based on piezo, tribo, and pyroelectric effect, and the first of its kind was developed in the year 2006 by Wang et al. The invention of nanogenerators is a breakthrough in the field of ambient energy-harvesting techniques as they are lightweight, easily fabricated, sustainable, and care-free systems. In this paper, a comprehensive review on fundamentals, performance, recent developments, and application of nanogenerators in self-powered sensors, wind energy harvesting, blue energy harvesting, and its integration with solar photovoltaics are discussed. Finally, the outlook and challenges in the growth of this technology are also outlined.