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  1. Venkatappa M, Sasaki N, Han P, Abe I
    Sci Total Environ, 2021 Nov 15;795:148829.
    PMID: 34252779 DOI: 10.1016/j.scitotenv.2021.148829
    While droughts and floods have intensified in recent years, only a handful of studies have assessed their impacts on croplands and production in Southeast Asia. Here, we used the Google Earth Engine to assess the droughts and floods and their impacts on croplands and crop production over 40 years from 1980 to 2019. Using the Palmer Drought Severity Index (PDSI) as the basis for determining the drought and flood levels, and crop damage levels, crop production loss in both the Monsoon Climate Region (MCR) and the Equatorial Climate Region (ECR) of Southeast Asia was assessed over 47,192 grid points with 10 × 10-kilometer resolution. We found that rainfed crops were severely affected by droughts in the MCR and floods in the ECR. About 9.42 million ha and 3.72 million ha of cropland was damaged by droughts and floods, respectively. We estimated a total loss of 20.64 million tons of crop production between 2015 and 2019. Rainfed crops in Thailand, Cambodia, and Myanmar were strongly affected by droughts, whereas Indonesia, the Philippines, and Malaysia were more affected by floods over the same period. Accordingly, four levels of policy interventions were prioritized by considering the geolocated crop damage levels.
  2. Morishita K, Hiramoto A, Michishita A, Takagi S, Osuga T, Lim SY, et al.
    J. Vet. Intern. Med., 2017 May;31(3):770-777.
    PMID: 28382699 DOI: 10.1111/jvim.14685
    BACKGROUND: Perflubutane microbubbles, a second-generation ultrasound contrast agent, are phagocytized by Kupffer cells. This characteristic may be useful to differentiate diffuse hepatic diseases in dogs.

    HYPOTHESIS/OBJECTIVES: To determine whether the washout ratio in the hepatic vein (HV) measured by contrast-enhanced ultrasonography (CEUS) can distinguish between inflammatory and noninflammatory hepatic disorders in dogs.

    ANIMALS: Forty-one client-owned dogs with hepatic disorders including 14 with hepatitis, 7 with primary hypoplasia of the portal vein (PHPV), 9 with congenital portosystemic shunt (cPSS), and 11 with other hepatopathy were enrolled. Six dogs without hepatic disease also were evaluated as healthy controls.

    METHODS: Dogs with hepatic disorders were prospectively included. Contrast-enhanced ultrasonography of the HV was performed for 2 minutes. Washout ratio was defined as the attenuation rate from peak intensity to the intensity at the end of the CEUS study.

    RESULTS: Washout ratio in the hepatitis group (median, 18.0%; range, 2.0-37.0%) was significantly lower than that of the PHPV (median, 52.2%; range, 11.5-86.3%), cPSS (median, 60.0%; range, 28.6-77.4%), other hepatopathy (median, 70.5%; range, 26.6-88.4%), and normal (median, 78.0%; range, 60.7-91.7%) groups. The area under the receiver operating characteristic curve for hepatitis was 0.960, with a 95% confidence interval (CI) of 0.853-0.990. Washout ratio ≤37.1% resulted in a sensitivity of 100% (95% CI, 78.5-100%) and specificity of 85.2% (95% CI, 67.5-94.1%) for the prediction of hepatitis.

    CONCLUSIONS AND CLINICAL IMPORTANCE: Washout ratio can distinguish hepatitis from the other noninflammatory disorders with high accuracy. This result might reflect impaired Kupffer cell phagocytosis in dogs with hepatitis.

  3. Nisa K, Lim SY, Osuga T, Yokoyama N, Tamura M, Nagata N, et al.
    J Vet Med Sci, 2018 Mar 24;80(3):453-459.
    PMID: 29398670 DOI: 10.1292/jvms.17-0525
    Quantitative contrast-enhanced ultrasonography (CEUS) enables non-invasive and objective evaluation of intestinal perfusion by quantifying the intensity of enhancement on the intestine after microbubble contrast administration. During CEUS scanning, sedation is sometimes necessary to maintain animal cooperation. Nevertheless, the effect of sedative administration on the canine intestinal CEUS is unknown. This study aimed to investigate the effect of sedation with a combination of butorphanol and midazolam on the duodenal CEUS-derived perfusion parameters of healthy dogs. For this purpose, duodenum was imaged following contrast administration (Sonazoid®, 0.01 ml/kg) in six healthy beagles before and after intravenous injection of a combination of butorphanol (0.2 mg/kg) and midazolam (0.1 mg/kg). Furthermore, hemodynamic parameters including blood pressure and heart rate were recorded during the procedure. Five CEUS derived perfusion parameters including time-to-peak (TTP), peak intensity (PI), area under the curve (AUC), wash-in and wash-out rates (WiR and WoR, respectively) before and after sedation were statistically compared. The result showed that no significant change was detected in any of perfusion parameters. Systolic and mean arterial pressures significantly reduced after sedative administration, but diastolic arterial pressure and heart rate did not significantly change. Moreover, no significant partial correlation was observed between perfusion parameters and hemodynamic parameters. Thus, we concluded that the combination did not cause significant influence in duodenal CEUS perfusion parameters and could be a good option for sedation prior to duodenal CEUS in debilitated dogs.
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