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Fulltext Photonic characterization of selected bioactive chemicals in Malaysian herbs

Abu Bakar, B., Md. Salleh, N.H., Amir Hashim, N.A., Sudin, A., Jusoh, S., Abdullah, M.Z.K.

International Food Research Journal, 2016;23(101):221-224.
MyJurnal

This work presents the characterization of selected bioactive compounds of local herbs
through their photonic spectrum. A Shimadzu spectrophotometer was used to map bioactive
compounds extracted from Andrographis paniculata, Ficus deltoidea, Orthosiphon stamineus
and Centella asiatica. Dominant peaks and repeatability were the determinant parameters
in this study. Absorbance peaks of bioactive compounds were calibrated against respective
standardized chemicals obtained from reputable suppliers. The results obtained indicated
that absorbance peaks from different bioactive compounds could be identified by photonic
spectrum. Most bioactive markers were detected within the wavelength range of 200 nm to 350
nm, using a Deuterium (190 nm to 450 nm) light source and corresponding refraction grating.
A mathematical relationship of concentration versus absorbance at different wavelengths for
selected bioactive compounds were identified. The significance of the photonic characterization
of these phytochemicals forms the basis for a mathematical model in a decision support system
of a proposed mobile sensor prototype development.
First record of the tree-frog genus Chiromantis from Borneo with the description of a new species (Amphibia: Rhacophoridae)

Matsui M, Shimada T, Sudin A

Zoolog Sci, 2014 Jan;31(1):45-51.
PMID: 24410495 DOI: 10.2108/zsj.31.45

We record a tree frog of the genus Chiromantis for the first time from outside the Southeast Asian continent and describe it as a new species, Chiromantis inexpectatus. The new species from the Malaysian state of Sabah, Borneo, is a small-sized Chiromantis (male snout-vent length ca. 22 mm), and is distinguished from all other members of the genus by the combination of the following morphological characteristics: dark stripes absent, but dark spots present on dorsum; a dark-brown lateral band present from snout tip to half of body, bordered ventrally by white stripe; third and fourth fingers less than half webbed; third finger disk wider than tympanum diameter; and inner metatarsal tubercle present. Significance of findings of this species from Borneo Island, as well as phylogeny and breeding habit of the genus Chiromantis, are briefly discussed.
A new species of Meristogenys (Amphibia, Anura, Ranidae) from Sabah, Borneo

Matsui M, Shimada T, Sudin A

Zoolog Sci, 2010 Jan;27(1):61-6.
PMID: 20064010 DOI: 10.2108/zsj.27.61

We describe a new species of torrent-dwelling ranid frog of the genus Meristogenys from the Crocker Range, western Sabah, northern Borneo. The new species, Meristogenys maryatiae, differs from congeners by the combination of: small body, males 31-37 mm and females 65-66 mm in snout-vent length; head narrower than long; eyes moderate, diameter subequal to snout; iris unicolored; legs long; ventral surface of tibia without heavy pigmentation; rear of thigh blotched dark brown and cream; toes fully webbed; outer metatarsal tubercle present; larval dental formula 7(4-7)/6(1).
Taxonomic relationships of Ansonia anotis Inger, Tan, and Yambun, 2001 and Pedostibes maculatus (Mocquard, 1890), with a description of a new genus (Amphibia, Bufonidae)

Matsui M, Yambun P, Sudin A

Zoolog Sci, 2007 Nov;24(11):1159-66.
PMID: 18348617 DOI: 10.2108/zsj.24.1159

Examination of types and recently collected specimens revealed that Ansonia anotis Inger, Tan, and Yambun, 2001 and Pedostibes maculatus (Mocquard, 1890), both described from Kinabalu, Sabah, Malaysia, are hardly differentiated morphologically. Analyses of a total of 2,427 bp of the 12S rRNA, tRNA(val), and 16S mitochondrial rRNA genes revealed that the two species are very close genetically. Thus A. anotis is regarded as conspecific and is synonymized with P. maculatus. Genetically, this species proved to form a lineage distinct from other bufonids from Southeast Asia, including species of Ansonia and Pedostibes. Because the species has also some unique morphological traits different from known bufonid genera, we propose to establish a new genus for Nectophryne maculata Mocquard, 1890.
Resurrection of Staurois parvus from S. tuberilinguis from Borneo (Amphibia, Ranidae)

Matsui M, Mohamed M, Shimada T, Sudin A

Zoolog Sci, 2007 Jan;24(1):101-6.
PMID: 17409723

Two forms of Staurois that are differentiated by body size occur parapatrically in the Crocker Range, Sabah, Borneo. Analyses of a total of 1,499 bp of the mitochondrial cytochrome b, 12S rRNA, and 16S rRNA genes revealed that the two forms could be completely split genetically. The two forms could be also clearly differentiated morphologically, not only by snout-vent length but also by the relative sizes of snout, eye, and finger disk. Comparisons of the two forms with all known species of the genus revealed the large and small forms to be S. tuberilinguis and S. parvus, respectively. The latter species has long been synonymized with the former, but we here consider them to represent different species.
Fulltext Incidence and Factors Associated With Post-Sternotomy Pain Syndrome in the National Heart Institute, Malaysia

Sudin A, Chong C, Hassan R

J Cardiothorac Vasc Anesth, 2024 Feb;38(2):466-474.
PMID: 38114372 DOI: 10.1053/j.jvca.2023.11.014

OBJECTIVE: To determine the incidence of poststernotomy pain syndrome (PSPS) after open cardiac surgery in 2021. To determine characteristics and assess the severity of symptoms in patients diagnosed with PSPS. To identify factors that can be associated with patients who were positive for PSPS.
DESIGN AND METHODOLOGY: This study used a retrospective observational approach. Logistic regression analysis was employed to identify factors associated with the positive group.
SETTING: This study included all adult patients who underwent open cardiac surgery at the National Heart Institute, Malaysia, in 2021.
PARTICIPANTS: A total of 1,395 patients were enrolled.
INTERVENTIONS: The study involved conducting phone interviews to assess the presence of PSPS, followed by administering the Brief Pain Inventory questionnaire in the positive group to identify characteristics and severity of chronic pain.
MEASUREMENTS AND MAIN RESULTS: The incidence of PSPS after open cardiac surgery in 2021 was 20.35%. A total of 17.7% of patients reported that pain affected their daily activities, sleep, or emotions. Univariate analysis identified factors associated with PSPS, including age <60 years old, body mass index >30 kg/m2, history of previous percutaneous coronary intervention, ejection fraction <50%, the absence of chronic kidney disease (CKD), and internal mammary artery harvesting (p < 0.05). Multivariate analysis revealed that 4 independent factors were associated with PSPS: age <60 years old, history of previous percutaneous coronary intervention, ejection fraction <50%, and the absence of CKD (as compared with CKD) (p < 0.05).
CONCLUSIONS: Poststernotomy pain syndrome is a complex issue affected by various factors. Although the pain score may not be as severe as previously believed, it remains crucial to recognize PSPS because a significant proportion of patients are affected.
Fulltext Molecular and hematological studies in a cohort of beta zero South East Asia deletion (β°-thal SEA) from Malaysian perspective

Yasin NM, Abdul Hamid FS, Hassan S, Sudin A, Yassim H, Mohd Sahid EN, et al.

Front Pediatr, 2022;10:974496.
PMID: 36533237 DOI: 10.3389/fped.2022.974496

ABSTRACT: We report the haematological parameters and molecular characterization of beta zero (β°) South East Asia (SEA) deletion in the HBB gene cluster with unusually high levels of Hb F compared to a classical heterozygous beta zero (β°)-thalassaemia.
METHODS: Retrospective study on 17 cases of (β°) South East Asia (SEA) deletion from 2016 to 2019 referred to Institute for Medical Research were conducted. The clinical information and haematological profiles were evaluated. The mutation was analyzed, and the results were compared with other β°-thalassaemia groups. For HBB gene genotyping, all the cases were subjected for multiplex gap-PCR, 5 cases were subjected for HBB gene sequencing for exclusion of compound heterozygous with other beta variants. Co-inheritance of α-thalassaemia were determined using multiplex gap-PCR and multiplex ARMS-PCR.
RESULTS: Seventeen cases were positive for β°-thal SEA deletion. Fifteen cases were heterozygous and two were compound heterozygous for β°-thal SEA deletion. The results were compared with 182 cases of various heterozygous β° deletions and mutations. The mean Hb for heterozygous β°-thal SEA deletion (13.44 ± 1.45 g/dl) was normal and significantly higher than heterozygous IVS 1-1 and Codon 41/42 (post hoc test, p