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Biolubricants from waste cooking oil: A review of extraction technologies, conversion techniques, and performance enhancement using natural antioxidants

Teh JL, Walvekar R, Ho KC, Khalid M

J Environ Manage, 2025 Feb;375:124267.
PMID: 39879924 DOI: 10.1016/j.jenvman.2025.124267

Effective management of agricultural and industrial by-products is essential for promoting circular economic practices and enhancing environmental sustainability. Agri-food wastes and waste cooking oil (WCO) represent two abundant residual streams with significant potential for sustainable biolubricant production. Valorizing biomass and WCO aligns with Sustainable Development Goal (SDG) 7, as it improves energy efficiency through enhanced lubricant performance and reduced energy loss. Furthermore, this sustainable approach contributes to SDG 12 and SDG 13 by minimizing waste production and accumulation, thereby mitigating negative environmental impacts and climate change. This critical review addresses existing gaps in the production of biolubricants from WCO and the incorporation of natural antioxidants as versatile additives. It examines and compares various techniques for the extraction, chemical and physical modification, and characterization of WCO-derived biolubricants. Specific methods, including esterification, transesterification, and antioxidant incorporation, are evaluated for their effectiveness in converting WCO into biolubricants. The review also discusses the influence of residual bioactive compounds on oxidative stability and lubricating properties. While vegetable oils demonstrate superior friction-reducing capabilities compared to petroleum-based lubricants, their triglyceride structure often results in poor oxidative stability, limiting their practical applications. Modification strategies and antioxidant inclusion are proposed to enhance this stability. A comprehensive analysis of the physicochemical properties and tribological performance of biolubricants, both pre- and post-processing, is presented. This systematic evaluation of extraction and upgrading methodologies aims to facilitate the development and industrial adoption of sustainable biolubricants.
Fulltext Rapid spheroid assays in a 3-dimensional cell culture chip

Teh JL, Abdul Rahman SF, Domnic G, Satiyasilan L, Chear NJY, Singh D, et al.

BMC Res Notes, 2021 Aug 13;14(1):310.
PMID: 34389056 DOI: 10.1186/s13104-021-05727-0

OBJECTIVE: The spheroid model provides a physiological platform to study cancer cell biology and drug sensitivity. Usage of bovine collagen I for spheroid assays is costly especially when experiments are conducted in 24-well plates, as high volume of bovine collagen I is needed. The aim of the study was to downsize spheroid assays to a microfluidic 3D cell culture chip and compare the growth, invasion and response to drug/compound of spheroids embedded in the 3D chip to spheroids embedded in 24-well plates.
RESULTS: Spheroids generated from nasopharyngeal carcinoma cell line HK-1 continuously grew and invaded into collagen matrix in a 24-well plate. Similar observations were noticed with spheroids embedded in the 3D chip. Large spheroids in both 24-well plate and the 3D chip disintegrated and invaded into the collagen matrix. Preliminary drug sensitivity assays showed that the growth and invasion of spheroids were inhibited when spheroids were treated with combination of cisplatin and paynantheine at high concentrations, in a 24-well plate. Comparable findings were obtained when spheroids were treated with the same drug combination in the 3D chip. Moving forward, spheroid assays could be performed in the 3D chip in a more high-throughput manner with minimal time and cost.
Asia Pacific Gastroesophageal Cancer Congress (APGCC) 2024 consensus statement on stage 2 and 3 locally advanced gastric and Siewert 3 junctional adenocarcinoma

Masuda Y, Fong KL, Yeo D, Yeo C, Chue KM, Araba SB, et al.

J Gastroenterol, 2025 Sep;60(9):1079-1090.
PMID: 40514519 DOI: 10.1007/s00535-025-02266-4

BACKGROUND: While the development in multimodal therapies has helped improve treatment outcomes for patients with locally advanced gastric adenocarcinoma (LAGC), there still exist disparities in opinion with an optimal treatment plan. This consensus hopes to provide clinicians with structured guidelines to aid in the decision-making for treatment options for LAGC.
METHODS: The consensus statement was initiated by establishing a taskforce in collaboration with the Asia Pacific Gastroesophageal Cancer Congress (APGCC) and a multidisciplinary expert panel was selected. Clinical questions on LAGC where perceived variance in practice or opinion may exist were formulated. Studies involving patients with Stage 2 or 3 gastric or Siewert 3 junctional cancers with treatment arms of perioperative chemotherapy, neoadjuvant chemotherapy, adjuvant chemotherapy, immunotherapy and surgery were included. A total of two rounds of voting were performed. Consensus was determined to be reached when a single answer or a combination of either "strongly agree/agree" or "strongly disagree/disagree" responses exceeded 75%.
RESULTS: A total of thirteen clinical questions were developed. They were identified through five main categories: Distal LAGC, Proximal LAGC, Deficient mismatch repair tumors, Chemotherapy and Immunotherapy, and Elderly/Unfit patients. After two rounds of voting by our multidisciplinary expert panel, eleven out of a total thirteen clinical questions had reached consensus. No consensus was reached for two clinical questions.
CONCLUSION: The APGCC consensus statement aims to guide clinicians in the treatment options for LAGC and Siewert 3 junctional cancer and has clarified some of the roles of perioperative chemotherapy and immunotherapy.

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