The objective of this study was to evaluate the in vitro antibacterial activities of methanol and aqueous extracts of P. pellucida aerial part (PPAP) against four multi-drug resistant organisms; methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended-spectrum beta-lactamase and carbapenem-resistant Enterobacteriaceae and four foodborne pathogens; Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhimurium. The antibacterial potentialities of the plant extracts were evaluated at 250 mg/ml and 500 mg/ml. Only susceptible bacteria were further determined for minimum inhibitory (MIC) and minimum bactericidal (MBC) concentrations. The best extract of a single dose of 5000 mg/kg PPAP methanol extract was acutely tested on female rats by adapting the OECD guidelines No 425. Findings obtained indicated that only PPAP methanol extract was found to be a potent inhibitor towards Bacillus cereus with the MIC and MBC values at 3.91 mg/ml and 7.81 mg/ml respectively. Toxicity study revealed that there was neither mortality nor morbidity and absent of abnormalities on all rats examined.