MyMedR

Displaying all 4 publications

Abstract:

Sort:

Fulltext Salicylate toxicity from ingestion of traditional massage oil

Muniandy RK, Sinnathamby V

BMJ Case Rep, 2012;2012.
PMID: 22922924 DOI: 10.1136/bcr-2012-006562

A 16-month-old child developed a brief generalised tonic-clonic fitting episode and vomiting at home, after accidental ingestion of traditional massage oil. As the patient presented with clinical features of salicylate toxicity, appropriate management was instituted. He was admitted to the intensive care unit for multiorgan support. The child was discharged well 1&emsp14;week after the incident. Methyl-salicylate is a common component of massage oils which are used for topical treatment of joint and muscular pains. However, these massage oils may be toxic when taken orally. Early recognition of the salicylate toxicity is very important in producing a good patient outcome.

Matched MeSH terms: Charcoal/therapeutic use
Effects of Fuller's Earth and activated charcoal on oral absorption of paraquat in rabbits

Idid SZ, Lee CY

Clin Exp Pharmacol Physiol, 1996 Aug;23(8):679-81.
PMID: 8886489

1. Thirty male rabbits of local strain (weighing 1.5-2 kg) were divided into five groups. Four groups were treated with an oral dose of paraquat, which was followed by either Fuller's Earth or activated charcoal 0.5 or 2.0 h later. The remaining group acted as the control group and was treated only with an oral dose of paraquat. The dose of paraquat was 20.0 mg/kg given in a concentration of 20.0 mg/mL. 2. Both adsorbents were administered in 15 mL normal saline as a 30% slurry. Blood was sampled from the ear vein 0.5, 1, 2, 4, 8 and 24h after the administration of paraquat. 3. Paraquat concentration was determined spectophotometrically at 600 nm by comparing against a standard curve of paraquat obtained by the addition of standard paraquat into normal rabbit serum and extracting interfering substances with ether. 4. The results of the present study show that either adsorbent can bring down the serum paraquat level. There was no significant difference found in the effectiveness of either adsorbent. 5. It is concluded that the administration of an adsorbent as early as possible will help in the reduction of paraquat absorption from the gastrointestinal tract. 6. Activated charcoal is still effective in lowering serum paraquat concentration when given more than 1 h after ingestion of paraquat.

Matched MeSH terms: Charcoal/therapeutic use*
Activated carbon cloth versus silver-based dressings in a population with diabetic foot ulcer: a randomised controlled trial

Bajuri MY, Nordin A

J Wound Care, 2024 May 02;33(5):298-303.
PMID: 38683771 DOI: 10.12968/jowc.2024.33.5.298

OBJECTIVE: Activated carbon cloth (ACC), known as Zorflex dressing, has emerged as an innovative approach in managing bacterial infection in diabetic foot ulcer (DFU) treatment. This pilot study was undertaken to determine the efficacy of Zorflex ACC dressing (Chemviron Carbon Cloth Division, UK) compared to standard silver-based dressing on DFUs.
METHOD: An open label, comparative, randomised controlled trial enrolling patients who attended the diabetic foot clinic was conducted between August 2022 and August 2023. The primary endpoint was a difference of 20% in wound area reduction with the ACC dressing compared to silver-based dressing within eight weeks. The secondary endpoints were proportion of complete healing, time to healing and adverse events.
RESULTS: The cohort comprised 40 patients. The mean wound reduction percentage at 8 weeks for patients in the ACC arm was 85.40±16.00% compared with 65.08±16.36% in the silver-based dressing arm. Complete healing was observed in six of 20 patients in the ACC arm compared to two of 20 in the silver-based dressing arm.
CONCLUSION: These data suggest that the ACC dressing promotes better ulcer healing in DFU patients than the silver-based dressing.

Matched MeSH terms: Charcoal/therapeutic use
Oral health: charcoal brushes

Ramachandra SS, Dicksit DD, Gundavarapu KC

Br Dent J, 2014 Jul 11;217(1):3.
PMID: 25012309 DOI: 10.1038/sj.bdj.2014.557
Matched MeSH terms: Charcoal/therapeutic use*