Displaying publications 21 - 23 of 23 in total

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  1. Fulltext Information needs on type 1 diabetes mellitus (T1DM) and its management in children and adolescents: a qualitative study
    Muhammed Elamin S, Muhamad Arshad NF, Md Redzuan A, Abdul Aziz SA, Hong J, Chua XY, et al.
    BMJ Open, 2024 Apr 02;14(4):e079606.
    PMID: 38569693 DOI: 10.1136/bmjopen-2023-079606
    OBJECTIVE: The objective of this study is to explore the information needs related to insulin therapy in children and adolescents with type 1 diabetes mellitus (T1DM) from the children's perspectives as well as their caregivers.

    DESIGN: Qualitative study; semistructured interviews. To identify emerging themes relating to information needs, open coding and thematic analysis were employed.

    SETTING: Participants were recruited from a tertiary care children's hospital in Kuala Lumpur, Malaysia and a specialist hospital in Riyadh, Saudi Arabia.

    PARTICIPANTS: Thirty one children with a mean age of 11.5 years (SD=1.9) and their caregivers were interviewed. Seventeen participants were from Malaysia and 14 were from Saudi Arabia.

    RESULTS: Four themes of information emerged from the interviews, including information related to (1) hypoglycaemia and hyperglycaemia, (2) insulin therapy, (3) injection technique and (4) other information needs pertaining to continuous glucose monitoring, access to peer groups and future advances in insulin therapy.

    CONCLUSION: This study provided valuable insights into the information needs related to T1DM and insulin therapy among children and adolescents with T1DM that should be considered by stakeholders in the development of age-appropriate education materials. Such materials will assist children and adolescents to better manage their life-long T1DM condition from adolescence until adulthood.

  2. Fulltext The effect of salt water ageing on the mechanical and rheological properties of magnetorheological elastomer
    Ahmad Khairi MH, Mazlan SA, Ubaidillah U, Khaidir REM, Nordin NA, Johari MAF, et al.
    Sci Rep, 2023 Apr 10;13(1):5810.
    PMID: 37037883 DOI: 10.1038/s41598-023-33171-6
    This paper aims to investigate the mechanical and rheological properties of magnetorheological elastomer (MRE) in marine ecosystems. The prepared samples comprised silicone rubber (SR) and 70 wt% micron-sized carbonyl iron particles (CIPs), immersed in an artificial marine ecosystem using salt water (Natrium Chloride) for 30 days. The mechanical properties of MRE samples were evaluated using hardness and quasi-static tensile tests. While the rheometer was used to investigate the rheological properties of their storage modulus condition with magnetic field stimulation. Further analysis of the defects and damages caused by salt water ageing was done through morphological observation using scanning electron microscope (SEM) technology. The results showed that the hardness and tensile strength of MRE samples that were soaked in salt water were affected over time. Lower values of hardness and tensile strength were obtained after 30 days due to the presence of Na+ and Cl-, which acted as an accelerator to the hydrolyzation process of the MRE. The process then, enhanced the water ingress capability into the matrix to cause the molecular changes. Interestingly, for rheological properties, 30 days of salt water ageing allowed the water molecules to move the MRE matrix molecular chains apart, a process known as plasticization and thus increasing the MR effect. Furthermore, morphological evidence was established to determine the MRE changes during salt water ageing. The research findings should greatly contribute to a better understanding of the effect of salt water on the performance of MRE.
  3. Major health impact of accelerated aging in young HIV-infected individuals on antiretroviral therapy
    Rajasuriar R, Chong ML, Ahmad Bashah NS, Abdul Aziz SA, Mcstea M, Lee ECY, et al.
    AIDS, 2017 06 19;31(10):1393-1403.
    PMID: 28358731 DOI: 10.1097/QAD.0000000000001475
    BACKGROUND: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge; however, studies assessing multidimensional aspects of aging are lacking. We characterized 10 geriatric conditions encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls.

    METHODS: HIV-infected individuals were recruited from the outpatient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged at least 25 years of age with no acute illness, and HIV-infected individuals were on stable ART. Geriatric conditions were assessed and the burden scored as a composite of geriatric conditions present in an individual (total score = 10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of geriatric conditions.

    RESULTS: We analyzed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, sex, and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV-positive cohort, median (interquartile range) age was 44 (38-51) years and CD4 T-cell count was 562 (398-737) cells/μl. The burden of geriatric conditions was significantly higher in the HIV-infected group compared with controls (P 
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