DNA computing, or more generally, molecular computing, is a recent development on computations using biological molecules, instead of the traditional silicon-chips. Some computational models which are based on different operations of DNA molecules have been developed by using the concept of formal language theory. The operations of DNA molecules inspire various types of formal language tools which include sticker systems, grammars and automata. Recently, the grammar counterparts of Watson-Crick automata known as Watson-Crick grammars which consist of regular, linear and context-free grammars, are defined as grammar models that generate double-stranded strings using the important feature of Watson-Crick complementarity rule. In this research, a new variant of static Watson-Crick linear grammar is introduced as an extension of static Watson-Crick regular grammar. A static Watson-Crick linear grammar is a grammar counterpart of sticker system that generates the double-stranded strings and uses rule as in linear grammar. The main result of the paper is to determine some computational properties of static Watson-Crick linear grammars. Next, the hierarchy between static Watson-Crick languages, Watson-Crick languages, Chomsky languages and families of languages generated by sticker systems are presented.
A mathematical model is considered to determine the effectiveness of disin-
fectant solution for surface decontamination. The decontamination process involved the
diffusion of bacteria into disinfectant solution and the reaction of the disinfectant killing
effect. The mathematical model is a reaction-diffusion type. Finite difference method and
method of lines with fourth-order Runge-Kutta method are utilized to solve the model
numerically. To obtain stable solutions, von Neumann stability analysis is employed to
evaluate the stability of finite difference method. For stiff problem, Dormand-Prince
method is applied as the estimated error of fourth-order Runge-Kutta method. MATLAB
programming is selected for the computation of numerical solutions. From the results
obtained, fourth-order Runge-Kutta method has a larger stability region and better ac-
curacy of solutions compared to finite difference method when solving the disinfectant
solution model. Moreover, a numerical simulation is carried out to investigate the effect
of different thickness of disinfectant solution on bacteria reduction. Results show that
thick disinfectant solution is able to reduce the dimensionless bacteria concentration more
effectively.
A new method to construct the distinct Hamiltonian circuits in complete
graphs is called Half Butterfly Method. The Half Butterfly Method used the concept
of isomorphism in developing the distinct Hamiltonian circuits. Thus some theoretical
works are presented throughout developing this method.
Real life phenomena found in various fields such as engineering, physics,
biology and communication theory can be modeled as nonlinear higher order ordinary
differential equations, particularly the Duffing oscillator. Analytical solutions for these
differential equations can be time consuming whereas, conventional numerical solutions
may lack accuracy. This research propose a block multistep method integrated with a
variable order step size (VOS) algorithm for solving these Duffing oscillators directly.
The proposed VOS Block method provides an alternative numerical solution by reducing
computational cost (time) but without loss of accuracy. Numerical simulations
are compared with known exact solutions for proof of accuracy and against current
numerical methods for proof of efficiency (steps taken).
A new topic of Zero Energy Building (ZEB) is getting famous in research area
because of its goal of reaching zero carbon emission and low building cost. Renewable
energy system is one of the ideas to achieve the objective of ZEB. Genetic Algorithm (GA)
is widely used in many research areas due to its capability to escape from a local minimal
to obtain a better solution. In our study, GA is chosen in sizing optimization of the
number of photovoltaic, wind turbine and battery of a hybrid photovoltaic-wind-battery
system. The aim is to minimize the total annual cost (TAC) of the hybrid energy system
towards the low cost concept of ZEB. Two GA parameters, which are generation number
and population size, have been analysed and optimized in order to meet the minimum
TAC. The results show that the GA is efficient in minimizing cost function of a hybrid
photovoltaic-wind-battery system with its robustness property.
Preventive maintenance (PM) planning becomes a crucial issue in the real world of the manufacturing process. It is important in the manufacturing industry to maintain the optimum level of production and minimize its investments. Thus, this paper focuses on multiple jobs with a single production line by considering stochastic machine breakdown time. The aim of this paper is to propose a good integration of production and PM schedule that will minimize total completion time. In this study, a hybrid method, which is a genetic algorithm (GA), is used with the Monte Carlo simulation (MCS) technique to deal with the uncertain behavior of machine breakdown time. A deterministic model is adopted and tested under different levels of complexity. Its performance is evaluated based on the value of average completion time. The result clearly shows that the proposed integrated production with PM schedule can reduce the average completion time by 11.68% compared to the production scheduling with machine breakdown time.
Dengue is a mosquito-borne disease caused by virus and found mostly in urban and semi-urban areas, in many regions of the world. Female Aedes mosquitoes, which usually bite during daytime, spread the disease. This flu-like disease may progress to severe dengue and cause fatality. A generic reaction-diffusion model for transmission of mosquito-borne diseases was proposed and formulated. The motivation is to explore the ability of the generic model to reproduce observed dengue cases in Borneo, Malaysia. Dengue prevalence in four districts in Borneo namely Kuching, Sibu, Bintulu and Miri are compared with simulations results obtained from the temporal and spatio-temporal generic model respectively. Random diffusion of human and mosquito populations are taken into account in the spatio-temporal model. It is found that temporal simulations closely resemble the general behavior of actual prevalence in the three locations except for Bintulu. The recovery rate in Bintulu district is found to be the lowest among the districts, suggesting a different dengue serotype may be present. From observation, the temporal generic model underestimates the recovery rate in comparison to the spatio-temporal generic model.
Markov map is one example of interval maps where it is a piecewise expanding
map and obeys the Markov property. One well-known example of Markov map is the
doubling map, a map which has two subintervals with equal partitions. In this paper, we
are interested to investigate another type of Markov map, the so-called skewed doubling
map. This map is a more generalized map than the doubling map. Thus, the aims of this
paper are to find the fixed points as well as the periodic points for the skewed doubling
map and to investigate the sensitive dependence on initial conditions of this map. The
method considered here is the cobweb diagram. Numerical results suggest that there exist
dense of periodic orbits for this map. The sensitivity of this map to initial conditions is
also verified where small differences in initial conditions give different behaviour of the
orbits in the map.
Recently, oil refining industry is facing with lower profit margin due to un-
certainty. This causes oil refinery to include stochastic optimization in making a decision
to maximize the profit. In the past, deterministic linear programming approach is widely
used in oil refinery optimization problems. However, due to volatility and unpredictability
of oil prices in the past ten years, deterministic model might not be able to predict the
reality of the situation as it does not take into account the uncertainties thus, leads to
non-optimal solution. Therefore, this study will develop two-stage stochastic linear pro-
gramming for the midterm production planning of oil refinery to handle oil price volatility.
Geometric Brownian motion (GBM) is used to describe uncertainties in crude oil price,
petroleum product prices, and demand for petroleum products. This model generates the
future realization of the price and demands with scenario tree based on the statistical
specification of GBM using method of moment as input to the stochastic programming.
The model developed in this paper was tested for Malaysia oil refinery data. The result
of stochastic approach indicates that the model gives better prediction of profit margin.
The box plot has been used for a very long time since 70s in checking the existence
of outliers and the asymmetrical shape of data. The existing box plot is constructed
using five values of statistics calculated from either the discrete or continous data. Many
improvement of box plots have deviated from the elegant and simplier approach of exploratory
data analysis by incorporating many other statistic values resulting the turning
back of the noble philosophy behind the creation of box plot. The modification using
range value with the minimum and maximum values are being incorporated to suit the
need of selected discrete distribution when outliers is not an important criteria anymore.
The new modification of box plot is not based on the asymmetrical shape of distribution
but more on the spreading and partitioning data into range measure. The new propose
name for the box plot with only three values of statistics is called range-box plot.
This journal renders the random walk behaviour of the Malaysian daily share return, through tests of efficient market hypothesis (EMH) based on three different financial periods, namely growth, financial crisis, and recovery period. This review also covers the behaviour of extreme return for weekly and monthly series generated from Block maxima-minima method. Autocorrelation Function test (ACF) and Ljung-Box test had been employed to measure average correlation between observations, while Augmented Dickey-Fuller (ADF), Phillips-Perron (PP), Kwiatkowski Phillips Schmidt Shin (KPSS) test had been used to scan the unit root and the stationarity. Multiple variance ratio tests had also been conducted to examine the random walk behaviour. Serial correlation test indicated that the movement of daily return during the financial crisis period was weak-form efficiency. The unit root and stationary tests suggested that each daily series was stationary, but trend stationary for extreme cases. Variance ratio tests indicated that the return during the recovery period was weak-form inefficiency due to the short lag autocorrelation in series.
Simulation is used to measure the robustness and the efficiency of the forecasting
techniques performance over complex systems. A method for simulating multivariate
time series was presented in this study using vector autoregressive base-process. By
applying the methodology to the multivariable meteorological time series, a simulation
study was carried out to check for the model performance. MAPE and MAE performance
measurements were used and the results show that the proposed method that consider
persistency in volatility gives better performance and the accuracy error is six time smaller
than the normal hybrid model.
A mechanistic model has been used to explain the effect of radiation. The
model consists of parameters which represent the biological process following ionizing
radiation. The parameters in the model are estimated using local and global optimiza-
tion algorithms. The aim of this study is to compare the efficiency between local and
global optimization method, which is Pattern Search and Genetic Algorithm respectively.
Experimental data from the cell survival of irradiated HeLa cell line is used to find the
minimum value of the sum of squared error (SSE) between experimental data and sim-
ulation data from the model. The performance of both methods are compared based on
the computational time and the value of the objective function, SSE. The optimization
process is carried out by using the built-in function in MATLAB software. The parameter
estimation results show that genetic algorithm is more superior than pattern search for
this problem.
In this work, a non-abelian metabelian group is represented by G while represents conjugacy class graph. Conjugacy class graph of a group is that graph associated with the conjugacy classes of the group. Its vertices are the non-central conjugacy classes of the group, and two distinct vertices are joined by an edge if their cardinalities are not coprime. A group is referred to as metabelian if there exits an abelian normal subgroup in which the factor group is also abelian. It has been proven earlier that 25 non-abelian metabelian groups which have order less than 24, which are considered in this work, exist. In this article, the conjugacy class graphs of non-abelian metabelian groups of order less than 24 are determined as well as examples of some finite groups associated to other graphs are given.
Replicated linear functional relationship model is often used to describe
relationships between two circular variables where both variables have error terms and
replicate observations are available. We derive the estimate of the rotation parameter
of the model using the maximum likelihood method. The performance of the proposed
method is studied through simulation, and it is found that the biasness of the estimates
is small, thus implying the suitability of the method. Practical application of the
method is illustrated by using a real data set.
Life table is a table that shows mortality experience of a nation. However, in Malaysia, the information in this table is provided in the five-years age groups (abridged) instead of every one-year age. Hence, this study aims to estimate the one-year age mor- tality rates from the abridged mortality rates using several interpolation methods. We applied Kostaki method and the Akima spline method to five sets of Malaysian group mortality rates ranging from period of 2012 to 2016. The result were then compared with the one-year mortality rates. We found that the method by Akima is the best method for Malaysian mortality experience as it gives the least minimum of sum of square errors. The method does not only provide a good fit but also, shows a smooth mortality curve.
In this paper, we look at the propagation of internal solitary waves over three
different types of slowly varying region, i.e. a slowly increasing slope, a smooth bump and
a parabolic mound in a two-layer fluid flow. The appropriate mathematical model for this
problem is the variable-coefficient extended Korteweg-de Vries equation. The governing
equation is then solved numerically using the method of lines. Our numerical simulations
show that the internal solitary waves deforms adiabatically on the slowly increasing slope.
At the same time, a trailing shelf is generated as the internal solitary wave propagates
over the slope, which would then decompose into secondary solitary waves or a wavetrain.
On the other hand, when internal solitary waves propagate over a smooth bump or a
parabolic mound, a trailing shelf of negative polarity would be generated as the results of
the interaction of the internal solitary wave with the decreasing slope of the bump or the
parabolic mound. The secondary solitary waves is observed to be climbing the negative
trailing shelf.
Invadopodia are finger-like protrusions located at subcellular membrane which can lead to cancer cell invasion. The formation of invadopodia involves several steps such as actin polymerizations, degradation of extracellular matrix which produce ligand and signal stimulation that is occurred from the binding of ligand with epidermal growth factor receptor. In this paper, a mathematical model of signal transduction is investigated. Both signal and ligand are represented by Laplace equation with Dirichlet boundary condition for each region. The cell membrane is treated as free boundary surface to separate any activity that occurred in intracellular and extracellular regions. The motion of the interface is taken as gradient of interior signal and the cell membrane is set as zero level set function. The problem is solved numerically using finite difference scheme of upwind, interpolation and extrapolation methods. The results showed that the formation of invadopodia is formed when protrusions exist on the cell membrane.
Subsea cable laying is a risky and challenging operation faced by engineers, due to many uncertainties arise during the operation. In order to ensure that subsea cables are laid out diligently, the analysis of subsea cable tension during the laying operation is crucial. This study focuses on the fatigue failure of cables that will cause large hang-off loads based on catenary configuration after laying operation. The presented problem was addressed using mathematical modelling with consideration for a number of defining parameters, which include external forces such as current velocity and design parameters such as cable diameter. There were two types of subsea cable tension analyses studied: tensional analysis of catenary configurations and tensional analysis of lazy wave configurations. The latter involved a buoyancy module that was incorporated in the current catenary configuration that reduced subsea cable tension and enhanced subsea cable lifespan. Both analyses were solved using minimization through the gradient- based approach concerning on the tensional analysis of the subsea cable in different configurations. Lazy wave configurations were shown to successfully reduce cable tension, especially at the hang-off section.
This study presents a mathematical model examining wastewater pollutant removal through
an oxidation pond treatment system. This model was developed to describe the reaction
between microbe-based product mPHO (comprising Phototrophic bacteria (PSB)), dissolved
oxygen (DO) and pollutant namely chemical oxygen demand (COD). It consists
of coupled advection-diffusion-reaction equations for the microorganism (PSB), DO and
pollutant (COD) concentrations, respectively. The coupling of these equations occurred
due to the reactions between PSB, DO and COD to produce harmless compounds. Since
the model is nonlinear partial differential equations (PDEs), coupled, and dynamic, computational
algorithm with a specific numerical method, which is implicit Crank-Nicolson
method, was employed to simulate the dynamical behaviour of the system. Furthermore,
numerical results revealed that the proposed model demonstrated high accuracy when
compared to the experimental data.