Hepatitis C is a liver disease caused by the hepatitis C virus: the virus can cause both acute and chronic hepatitis infection. Patients with chronic hepatitis C virus (HCV) infection appear to have an excellent chance of responding to 6 months of standard therapy with interferon (IFN) and frequently develop systemic iron overload, which exacerbates morbidity. The iron excess in hepatitis C may be due to hereditary hemochromatosis, hematologic diseases, multiple transfusions, porphyria cutanea tarda and chronic alcohol abuse. Different mechanisms proposed to explain the relation between HCV infection and hepatic iron overload. Some revealed that hepatic iron accumulation results from release of iron from damaged liver cells. Consumption of coffee, tea also reduces iron absorption and thereby decrease iron overload in Liver and thereby reduces the oxidative stress of iron overload in liver. The global scenario of this problem has been discussed in the article.
Background: In Africa high prevalence of overweight and obesity was found in regions of East Africa (0.3%),
West Africa (0.7%), Central Africa (0.2%), South Africa (3.8%), and North Africa (12.5%).
Aims: This meta-analysis aimed to analyze the prevalence of obesity among young adults, aged 18-25 years
from five African countries.
Methods: The Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines were applied to
search published studies. of the 100 studies published as found in scientific databases from 2010 to 2017, only
five were selected. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
checklist was used to eliminate other studies.
Outcomes: A total of 22,320 obese young adults were analyzed to be prevalent. The obesity among adults in
SouthAfrica was found to be correlated with less physical activities. In Uganda, the prevalence of obesity is
683 which relates with their sedentary lifestyle and socio-demography. Among 371 young adults in Nigeria, the
prevalence of obesity was 5.1% among male and 10% among female related to diet and other consumptions.
Among 646 adults in Ghana, the prevalence of general obesity was observed to be related to genetics.
Conclusion: Prevalence of the male gender was 9,509 having a p=0.284 (at 95% C.I.±4,440.87845-
8,788.87845) with a mean score of 1,251, and a SD= 61,066. While the prevalence of obesity on females was
10,874 having a p= 0.00019, (at 95% C.I.±3,592.07-6,094.07) with a mean score of 2,174, and SD= 3,375.
Viability of cultured mammalian cells is evaluated by a variety of techniques. In this study, experimental results
of fast cell viability assays were compared to reveal the most suitable method for determination of
hyperthermia effect on viability of human breast cancer Michigan Cancer Foundation-7 (MCF-7) cell line. The
cells were exposed to heat at 42˚C for 2 hours to estimate the percentage of cell viability using four assays
(trypan blue, lactate dehydrogenase (LDH), and crystal violet, (CV). There was a mild decrease in percentage
of cell viability as the duration of heat exposure increased. Of the three counting techniques, the crystal violet
nuclei showed consistent and significantly higher value (70.58±1.97) than trypan blue and LDH assay
(81.07±20.12 and 77.06±11.84 respectively) (p< 0.05). This study reveals that CVwas the most sensitive assay
for adherent cell. It is also very effective; simple; and permits many samples to be analyzed rapidly and
simultaneously.
This study identied factors that contributed to the effectiveness of antihypertensive drugs and investigated the
most effective antihypertensive drug in controlling blood pressure. The purposive sampling technique was
used in this quasi-experimental design to enroll study participants. Of the 120 hypertensive patients following
consultations at a district hospital of Oluvil, only 100 complied with the experiment. Following medical checkup,
it was investigated that hypertension were controlled within 3 months affected by age, and gender. Gender,
more probable were women, was primarily identied as a factor (p=0.002657); and age bracket of 30-40 years
old was also identied as a factor to had helped control blood pressure (p=0.002107). Hypertensive drugs such
as Calcium Channel Blockers (p=0.0008712), Angiotensin Receptor Antagonist (p=0.03983), and
Angiotensin Converting Enzymes Inhibitors (p=0.04719) at normal dosages controlled blood pressures
among Sri Lankan hypertensive patients.
Meta-analysis is a subset of systematic review; a technique for systematically combining pertinent qualitative
and quantitative study data from numerous selected studies to broaden a single conclusion that has more
statistical power. This inference is statistically stronger than the analysis of any single study, due to increase
numbers of topics, greater variety amongst subjects, or collected effects and outcomes. The aim of this review
article is to highlight the definition, history, purpose, characteristics, use, advantage, disadvantage, validity,
and steps in conducting meta-analysis.