OBJECTIVES: In this study, we aimed to assess the incremental value of V/Q SPECT/CT over conventional V/Q planar scintigraphy and V/Q SPECT, and to determine if Q only-SPECT/CT without the conventional ventilation component could replace the current imaging protocol in diagnosing pulmonary embolism.
METHODS: We retrospectively assessed 73 patients with suspicion of pulmonary embolism who had undergone/Q planar scintigraphy, V/Q SPECT and V/Q SPECT/CT consecutively. Combination of clinical follow-up, laboratory test results and correlative imaging were used as reference standard. Q-only SPECT/CT datasets were then analysed separately without the V-planar, V-SPECT and V-SPECT/CT datasets.
RESULTS: A total of 66 patients fulfilled our initial inclusion and exclusion criteria, with 23 patients as positive for PE and 43 patients ruled out of having PE based on the reference standard. Sensitivity and specificity for V/P planar scintigraphy, V/Q SPECT, and V/Q SPECT-CT were 86.9% and 39.5%, 91.3% and 55.8%, and 100% and 97.6% respectively. Overall, SPECT/CT resulted in significantly higher diagnostic accuracy than planar and SPECT imaging respectively (p<0.05). Q-only SPECT/CT significantly over diagnosed pulmonary embolism in 12 patients (p<0.05).
CONCLUSION: Adding V/Q SPECT/CT to the algorithm of PE significantly improves the sensitivity and specificity. However, by eliminating the ventilation component, the diagnostic accuracy is significantly reduced.
PURPOSE: This study aims to semiquantitatively evaluate the standardized uptake value (SUV) of 99mTc-methylene diphosphonate (MDP) radionuclide tracer in the normal vertebrae of breast cancer patients using an integrated single-photon emission computed tomography (SPECT)/computed tomography (CT) scanner.
OVERVIEW OF LITERATURE: Molecular imaging techniques using gamma cameras and stand-alone SPECT have traditionally been utilized to evaluate metastatic bone diseases. However, these methods lack quantitative analysis capabilities, impeding accurate uptake characterization.
METHODS: A total of 30 randomly selected female breast cancer patients were enrolled in this study. The SUV mean (SUVmean) and SUV maximum (SUVmax) values for 286 normal vertebrae at the thoracic and lumbar levels were calculated based on the patients' body weight (BW), body surface area (BSA), and lean body mass (LBM). Additionally, 106 degenerative joint disease (DJD) lesions of the spine were also characterized, and both their BW SUVmean and SUVmax values were obtained. A receiver operating characteristic (ROC) curve analysis was then performed to determine the cutoff value of SUV for differentiating DJD from normal vertebrae.
RESULTS: The mean±standard deviations for the SUVmean and SUVmax in the normal vertebrae displayed a relatively wide variability: 3.92±0.27 and 6.51±0.72 for BW, 1.05±0.07 and 1.75±0.17 for BSA, and 2.70±0.19 and 4.50±0.44 for LBM, respectively. Generally, the SUVmean had a lower coefficient of variation than the SUVmax. For DJD, the mean±standard deviation for the BW SUVmean and SUVmax was 5.26±3.24 and 7.50±4.34, respectively. Based on the ROC curve, no optimal cutoff value was found to differentiate DJD from normal vertebrae.
CONCLUSIONS: In this study, the SUV of 99mTc-MDP was successfully determined using SPECT/CT. This research provides an approach that could potentially aid in the clinical quantification of radionuclide uptake in normal vertebrae for the management of breast cancer patients.