MyMedR

Observations of a retired professor

MEKIE DE

Med J Malaya, 1960 Dec;15:85-91.

PMID: 13769127

Matched MeSH terms: Tropical Medicine*

The integrity of medicine

SREENIVASAN BR

Med J Malaya, 1957 Jun;11(4):312-4.

PMID: 13482569

Matched MeSH terms: Medicine*

Historical synopsis of preventive medicine in Singapore

Malayan Medical Journal, 1930;5:97-102.

Matched MeSH terms: History of Medicine; Preventive Medicine

Interpretation of radiomics features-A pictorial review

Abbasian Ardakani A, Bureau NJ, Ciaccio EJ, Acharya UR

Comput Methods Programs Biomed, 2022 Mar;215:106609.

PMID: 34990929 DOI: 10.1016/j.cmpb.2021.106609

Radiomics is a newcomer field that has opened new windows for precision medicine. It is related to extraction of a large number of quantitative features from medical images, which may be difficult to detect visually. Underlying tumor biology can change physical properties of tissues, which affect patterns of image pixels and radiomics features. The main advantage of radiomics is that it can characterize the whole tumor non-invasively, even after a single sampling from an image. Therefore, it can be linked to a "digital biopsy". Physicians need to know about radiomics features to determine how their values correlate with the appearance of lesions and diseases. Indeed, physicians need practical references to conceive of basics and concepts of each radiomics feature without knowing their sophisticated mathematical formulas. In this review, commonly used radiomics features are illustrated with practical examples to help physicians in their routine diagnostic procedures.

Matched MeSH terms: Precision Medicine*

Vampire tourism and vampirism: the darker side of travel medicine

Rainford AC, Flaherty GT, Hallahan B

J Travel Med, 2023 Jun 23;30(4).

PMID: 36377759 DOI: 10.1093/jtm/taac135

Matched MeSH terms: Travel Medicine*

Precision medicine in lupus nephritis

Sharafaldin ENK, Sim MS, Lim SK, Alhussieni K, Huri HZ

Clin Chim Acta, 2024 Aug 15;562:119894.

PMID: 39068963 DOI: 10.1016/j.cca.2024.119894

Lupus nephritis (LN) is a prominent manifestation of systemic lupus erythematosus (SLE), characterized by diverse clinical and histopathological features, imposing a substantial burden on patients. Although the exact cause of SLE remain undetermined, several genetic, epigenetics, hormonal, and other factors are implicated in LN pathogenesis. The management of LN rely on invasive renal biopsies, while the standard therapy of the proliferative form of LN remains empirical and relies on indiscriminate immunosuppressants (IS). These treatments exhibit unsatisfactory remission rates, trigger recurrent renal flares, and entail grave adverse effects (ADEs). The advent of precision medicine into LN entails a concentrated effort to pinpoint essential biomarkers, reshaping the landscape of LN management. The primary objective of this review is to synthesize and summarize existing research findings by elucidating the most prevalent immunological, genetic, and epigenetic alterations and deliberate on management strategies that can pave the way for precision medicine in tackling LN. Novel clinical biomarker such as serum anti-complement component 1q (anti-C1q), with urinary markers including neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP1) and tumour necrosis-like weak inducers of apoptosis (TWEAK) are strongly correlated with LN. These biomarkers have good sensitivity and specificity and perform better than conventional biomarkers in assessing LN activity. Similarly, more renal-specific genetic and epigenetic alteration have been correlated with LN susceptibility and severity. This includes variants of hyaluronan synthase 2 (HAS2), and platelet-derived growth factor receptor alpha (PDGFRA). In the future, integrating clinical, genetic, epigenetic, and targeted therapies holds promise for guiding precision medicine and improving LN outcomes.

Matched MeSH terms: Precision Medicine*

Evidence-Based Traditional Medicine for Transforming Global Health and Well-Being

Patwardhan B, Wieland LS, Aginam O, Chuthaputti A, Ghelman R, Ghods R, et al.

J Integr Complement Med, 2023 Sep;29(9):527-530.

PMID: 37713586 DOI: 10.1089/jicm.2023.29121.editorial

Matched MeSH terms: Medicine, Traditional*

Synthesis and perspectives from the Ottawa 2022 conference on the assessment of competence

Boursicot K, Kemp S, Norcini J, Nadarajah VD, Humphrey-Murto S, Archer E, et al.

Med Teach, 2023 Sep;45(9):978-983.

PMID: 36786837 DOI: 10.1080/0142159X.2023.2174420

INTRODUCTION: The Ottawa Conference on the Assessment of Competence in Medicine and the Healthcare Professions was first convened in 1985 in Ottawa. Since then, what has become known as the Ottawa conference has been held in various locations around the world every 2 years. It has become an important conference for the community of assessment - including researchers, educators, administrators and leaders - to share contemporary knowledge and develop international standards for assessment in medical and health professions education.

METHODS: The Ottawa 2022 conference was held in Lyon, France, in conjunction with the AMEE 2022 conference. A diverse group of international assessment experts were invited to present a symposium at the AMEE conference to summarise key concepts from the Ottawa conference. This paper was developed from that symposium.

RESULTS AND DISCUSSION: This paper summarises key themes and issues that emerged from the Ottawa 2022 conference. It highlights the importance of the consensus statements and discusses challenges for assessment such as issues of equity, diversity, and inclusion, shifts in emphasis to systems of assessment, implications of 'big data' and analytics, and challenges to ensure published research and practice are based on contemporary theories and concepts.

Matched MeSH terms: Medicine*

Traditional Chinese medicine in the treatment of adverse reactions after TACE for primary hepatic carcinoma: Effect, mechanism, and potential advantages

Li HB, Huang L, Ni JY, Lin RY, Xi SY

Phytomedicine, 2024 Dec;135:156244.

PMID: 39556987 DOI: 10.1016/j.phymed.2024.156244

Primary hepatic carcinoma is one of the most common malignant tumors. China is a major country for liver cancer, accounting for about 50 % of the patients worldwide. Although there are a variety of treatments for primary hepatic carcinoma, chemotherapy remains an important method, and transcatheter arterial chemoembolization (TACE) is a commonly used local chemotherapy. Currently, there are no effective therapeutic measures to target adverse reactions generated after chemoembolization. A new approach is needed to alleviate post-TACE syndrome. Clinical and experimental studies have shown that traditional Chinese medicine can reduce adverse reactions and improve clinical efficacy when combined with primary hepatic carcinoma treatment. This suggests that traditional Chinese medicine plays an important and irreplaceable role in alleviating adverse reactions after TACE. However, there is still a need for high-quality experimental and clinical studies to obtain evidence of effective treatment.

Matched MeSH terms: Medicine, Chinese Traditional*

Medical arrangements in Malaya during the emergency 1948-49

BLUETT D

J R Army Med Corps, 1950 Jul;95(1):14-27.

PMID: 15437527

Matched MeSH terms: Military Medicine*; Naval Medicine*

Lessons on operations Malaya

DOW DC

J R Army Med Corps, 1950 Sep;95(3):164-6.

PMID: 14784967

Matched MeSH terms: Military Medicine*; Naval Medicine*

A long-range jungle operation in Malaya--1951

FORSTER MO

J R Army Med Corps, 1951 Nov;97(5):328-39.

PMID: 14889520

Matched MeSH terms: Military Medicine*; Naval Medicine*

Some medical problems of parachuting in Malaya

CONWAY SM, CREMIN BJ

J R Army Med Corps, 1956 Jan;102(1):70-2.

PMID: 13307652

Matched MeSH terms: Military Medicine*; Naval Medicine*

The medical natural history of Malayan aborigines

POLUNIN I

Med J Malaya, 1953 Dec;8(2):114A-74; concl.

PMID: 13164686

Matched MeSH terms: Medicine*; Tropical Medicine*

Some superstitious beliefs occurring in the theory and practice of Malay medicine

Gimlette JD

Journal of the Straits Branch of the Royal Asiatic Society, 1913.

Matched MeSH terms: Medicine, Traditional

The London school of hygiene and tropical medicine

Malayan Medical Journal, 1929;4:145-7.

Matched MeSH terms: Tropical Medicine

Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application

Karimi K, Mojtabavi S, Tehrany PM, Nejad MM, Rezaee A, Mohtashamian S, et al.

Int J Biol Macromol, 2023 Jul 01;242(Pt 3):124935.

PMID: 37230442 DOI: 10.1016/j.ijbiomac.2023.124935

The field of nanomedicine has provided a fresh approach to cancer treatment by addressing the limitations of current therapies and offering new perspectives on enhancing patients' prognoses and chances of survival. Chitosan (CS) is isolated from chitin that has been extensively utilized for surface modification and coating of nanocarriers to improve their biocompatibility, cytotoxicity against tumor cells, and stability. HCC is a prevalent kind of liver tumor that cannot be adequately treated with surgical resection in its advanced stages. Furthermore, the development of resistance to chemotherapy and radiotherapy has caused treatment failure. The targeted delivery of drugs and genes can be mediated by nanostructures in treatment of HCC. The current review focuses on the function of CS-based nanostructures in HCC therapy and discusses the newest advances of nanoparticle-mediated treatment of HCC. Nanostructures based on CS have the capacity to escalate the pharmacokinetic profile of both natural and synthetic drugs, thus improving the effectiveness of HCC therapy. Some experiments have displayed that CS nanoparticles can be deployed to co-deliver drugs to disrupt tumorigenesis in a synergistic way. Moreover, the cationic nature of CS makes it a favorable nanocarrier for delivery of genes and plasmids. The use of CS-based nanostructures can be harnessed for phototherapy. Additionally, the incur poration of ligands including arginylglycylaspartic acid (RGD) into CS can elevate the targeted delivery of drugs to HCC cells. Interestingly, smart CS-based nanostructures, including ROS- and pH-sensitive nanoparticles, have been designed to provide cargo release at the tumor site and enhance the potential for HCC suppression.

Matched MeSH terms: Precision Medicine

Fulltext Advancing Academic Capacity in Physical and Rehabilitation Medicine to Strengthen Rehabilitation in Health Systems Worldwide: A Joint Effort by the European Academy of Rehabilitation Medicine, the Association of Academic Physiatrists, and the International Society of Physical and Rehabilitation Medicine

Frontera WR, Stucki G, Engkasan JP, Francisco GE, Gutenbrunner C, Hasnan N, et al.

Am J Phys Med Rehabil, 2022 Sep 01;101(9):897-904.

PMID: 35777886 DOI: 10.1097/PHM.0000000000002067

Matched MeSH terms: Medicine*; Physical and Rehabilitation Medicine*

Fulltext Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, et al.

Nat Med, 2023 Oct;29(10):2438-2457.

PMID: 37794253 DOI: 10.1038/s41591-023-02502-5

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.

Matched MeSH terms: Evidence-Based Medicine; Precision Medicine*

Black magic and illness in a Malaysian Chinese community

Mo B

Soc Sci Med, 1984;18(2):147-57.

PMID: 6701559

Ah Yuk Je is a successful Hakka Chinese spirit medium practicing in a small Chinese community in Malaysia. Her clientele consists largely of young children suffering from a culturally specific condition called haak geng or 'soul loss' and women concerned about infertility, prenatal problems and errant spouses. While in a trance state, assisted by her tutelary spirits, she diagnoses, prescribes and treats illnesses. Her treatment includes naturalistic and magico-religious elements such as 'cooling' herbal teas, tonics to strengthen the body, rituals and amulets. Because Ah Yuk Je is a wife and mother, women find her sympathetic and astute at solving family problems. When faced with an illness herself, which she suspects to be the result of kong tao (black magic) instigated by someone in her own village, she seeks assistance from a healer outside her own ethnic group as well as outside her community. Four important factors influence Ah Yuk Je's decision to seek out this healer. The first two, recommendation from a trusted friend and a positive previous experience, are obvious, and require no further discussion. The remaining factors are the special nature of the illness, which requires treatment from a specialist, and her practice as a spirit medium. Successful spirit mediums are perceived to have a certain immunity to and control over supernatural forces. Thus the need for secrecy when a spirit medium becomes the victim of evil forces. She is able to preserve her professional reputation by consulting someone outside her ethnic group of potential clients as well as outside her physical community.

Matched MeSH terms: Medicine, Chinese Traditional*; Medicine, East Asian Traditional*; Medicine, Traditional*

Displaying publications 41 - 60 of 1461 in total