METHODS: Telephonic interviews were conducted using a pre-validated interview guide among community pharmacists. Purposive sampling was used to ensure heterogeneity of participants in terms of gender, age, and position in the pharmacy. The interview was conducted until a point where no new information was obtained. Interview data were thematically analyzed.
RESULTS: The analysis identified nine themes organized into four domains. The results revealed that pharmacists have positive perceptions of the safe disposal of medicines. Pharmacists mentioned that medicine returns to service in community pharmacies are not common due to a lack of facilities in the management of unwanted, expired, and returned medicines. As such pharmacists have suggested a few ways to minimize medicinal wastage.
CONCLUSIONS: Respondents aimed to minimize medicines wastage (unused medicines) in order to minimize loss of revenue. Respondents did not usually accept returned medicines due to the operational costs of safe disposal. Disposal of unused medicines was undertaken by centralizing the stocks at an organization facility before being disposed of by outsourced waste management companies.
METHODS: In this study, 25 patients with patellofemoral pain syndrome were enrolled, comprising of an intervention group of 13 patients who received IASTM treatment and a control group of 12 patients who received Tui-na manipulation therapy. The treatment cycle lasted for 4 weeks, featuring two interventions per week. Before treatment, the visual analog pain scale (VAS) of the knee, Lysholm score of the knee, modified Thomas test (MTT), and maximum isometric strength of the extensor muscles of the lower limbs were measured and recorded for both groups. After the first and last treatments, the aforementioned indexes were reassessed, and the maximum isometric muscle strength of the lower extremity extensors was measured only after 4 weeks of treatment had been completed.
RESULTS: There was no significant difference in the basic information of the two intervention groups (p > 0. 05). After the first treatment and 4 weeks of treatment, the Lysholm score in both groups significantly improved (p
METHODS: This study encompassed a cohort of 224 older women. Each participant underwent both 2D mammography and digital breast tomosynthesis examinations. Supplementary views were conducted when necessary, including spot compression and magnification, ultrasound, and recommended biopsies. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) were calculated for 2D mammography, DBT, and ultrasound. The impact of DBT on diminishing the need for supplementary imaging procedures was predicted through binary logistic regression.
RESULTS: In dense breast tissue, DBT exhibited notably heightened sensitivity and NPV for lesion detection compared to non-dense breasts (61.9% vs. 49.3%, p 0.05) between DBT and the four dependent variables.
CONCLUSION: Our findings indicate that among older women, DBT does not significantly decrease the requirement for further medical examinations.
METHOD: Potential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis.
RESULT: MIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions.
CONCLUSION: MIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier: CRD 42024517940.
METHODS: A convenience sample of 39 Year 3 dental students (25 women and 14 men, mean age = 22) enrolled in a Bachelor of Dental Surgery program at a private dental school in Malaysia participated in a week-long Padlet-based peer feedback activity focused on periodontics. Thematic analysis was conducted on student interactions and reflections collected from Padlet posts and individual student reflections.
RESULTS: The study yielded promising outcomes. Padlet's asynchronous and anonymous nature fostered in-depth discussions, broader participation, and constructive feedback. Students reported a boost in confidence, increased engagement, and a sense of camaraderie. Thematic analysis revealed the successful application of Nicol and MacFarlane's feedback principles, including clarifying expectations, promoting self-assessment, facilitating teacher-student dialogue, and encouraging reflection and action.
CONCLUSION: The findings of this study suggest that Padlet, with its unique features, offers a valuable tool for educators seeking to foster collaborative learning and feedback literacy in dental education. Padlet's affordances can significantly enhance collaborative learning and feedback literacy, promoting a trusting environment for student-centered learning and self-regulation in dental education. The study's findings suggest that Padlet can foster cognitive flexibility, allowing students to consider multiple perspectives and adapt their thinking. The platform's asynchronous nature and anonymity feature appeared to contribute to a sense of community and psychological safety, fostering trust among students. The findings of this study have practical implications for educators seeking to implement effective feedback practices and leverage technology to create engaging learning experiences that foster trust, collaboration, and, ultimately, student success.
METHOD: A scoping review was conducted following the framework of Arksey and O'Malley. The following electronic databases were searched: Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, Web of Science, Psychology and Behavioral Sciences Collection, PubMed, and Google Scholar. Gray literature was also searched through Google Scholar and ProQuest. Studies included reports on nursing students' emotional changes due to educational engagements with older adults.
RESULTS: A total of 3,001 abstracts were screened, with 78 full texts reviewed, resulting in 9 studies being included in the analysis. The results demonstrate that interactions with older adults enhance nursing students' empathy and emotional intelligence while fostering positive changes in their caring behaviors. Participants reported greater sensitivity to the feelings and physical discomforts of older adults, contributing to improved care and stronger relational dynamics.
DISCUSSION: Community-based education programs involving older adults represent an effective strategy for enhancing nursing students' empathy, emotional intelligence, and caring behaviors, suggesting valuable implications for nursing education methodologies.
OBJECTIVE: The present study analyzes the expression of H19 correlated with clinicopathological parameters, tobacco habit, loco-regional recurrence, and overall survival.
METHODS: A longitudinal study was undertaken using 96 formalin-fixed paraffin-embedded (FFPE) OSCC tissues and 30 FFPE adjacent normal mucosa (NM) tissues from patients who had surgery between 2015 and 2018. The tissues were subjected to quantitative reverse-transcription PCR (qRT-PCR) to determine H19 expression. The differential expression levels of H19 in OSCC were compared to clinicopathological variables and risk habits using the t-test and ANOVA. H19 expression correlated overall survival was analyzed by drawing the Kaplan-Meier curve followed by the log-rank test. A multivariate Cox proportional hazards regression analysis was performed to determine the ability of H19 to independently predict loco-regional recurrence and overall survival for OSCC.
RESULT: H19 was significantly underexpressed in OSCC compared to NM in both the study cases and the TCGA OSCC database. The lower expression of H19 was significantly associated with the tobacco smoking habit and was not associated with any clinical or pathological features. Multivariate Cox's proportional hazards regression analysis indicated that low H19 expression and positive lymph node metastasis were independent predictors of overall survival for OSCC. Higher age, higher TNM staging, and low H19 expression were independent predictors of loco-regional recurrence.
CONCLUSION: The findings in the present study indicate that H19 is a novel prognostic marker and may provide a therapeutic strategy for the targeted treatment of OSCC, and tobacco may play a role in the expression of H19.