Introduction: Tuberculosis negatively impacts the patients’ quality of life (QoL). Information on QoL among tuber-culosis patients may highlight gaps in the current management of the disease by identifying target groups with lower QoL. This study aimed to identify the sociodemographic factors associated with QoL among patients followed up in an urban tertiary hospital. Methods: A cross sectional study was conducted among adults with drug-sensitive pulmonary tuberculosis, selected using simple random sampling method, in the Institute of Respiratory Medicine, Kuala Lumpur. The WHOQOL BREF was utilised to evaluate the physical, psychological, social relationships and environment domains of QoL. Descriptive analysis and univariate analyses to test association between independent sociodemographic factors and QoL domain mean scores were done. Results: A total of 237 patients participated with a response rate of 96.34%. The factor associated with the physical domain was sex (t = 2.06, p = 0.04), whilst age (F = 3.77, p = 0.02), sex (t = 4.04, p < 0.001), marital status (F = 3.09, p = 0.04) and education level (F = 4.92, p = 0.008) were associated with the social relationships domain. Age (F = 3.55, p = 0.03), sex (t = 2.12, p = 0.03), edu-cation level (F = 7.97, p < 0.001) and monthly household income (F = 3.57, p = 0.03) were factors associated with the environment domain. No sociodemographic factors were associated with the psychological domain in this study. Conclusion: Patients who were younger, female, married, had tertiary education or monthly household income of more than RM6000 were associated with higher QoL. Targeted interventions among the sociodemographic groups with lower QoL could complement current clinical management to improve tuberculosis patients’ QoL.
Introduction: Adolescent aggression has become a serious public health problem with the escalating juvenile cases and violence among secondary school students by inflicting harm to others. The objective of this study was to deter-mine the biopsychosocial predictors of adolescent aggression among Form Four students in Hulu Langat. Methods: Cross-sectional study was conducted by proportionate population sampling method among Form Four students from all public secondary schools in Hulu Langat. Pre-tested questionnaires distributed to measure students’ ag-gression, demographic (ethnicity, family income), biological (sex, head injury, nutritional deficiency, breakfast skip-ping), psychological (attitude towards aggression, normative beliefs to aggression, personality trait, and emotional intelligence), and social factors (family environment, single parent status, domestic violence, peer deviant affiliation, alcohol, smoking, and substance abuse). Data was analysed using multivariate analysis to determine the significant predictors. Results: 480 students from four randomly selected schools participated in the study with response rate of 96.5%. The median aggression score was low, which was 23.00 (IQR=12.00). From simple linear regression, 15 factors had significant relationship with adolescent aggression. The predictors of adolescent aggression were lower family income, Malay ethnicity, nutritional deficiency, attitude towards aggression, and peer deviant affiliation (F [8, 244] =15.980, p-value
Introduction: Adolescent aggression is an important public health concern with escalating prevalence of juvenile cases and violence among these age groups including robbery, homicide, and gang fights. The objectives of this study protocol are to determine the biopsychosocial predictors and explore the contextual factors of adolescent ag- gression among secondary school students in Hulu Langat. Methods: Explanatory mixed method study design will be used, consist of quantitative cross-sectional study followed by basic qualitative study. Proportionate population sampling among Form 4 secondary school students from selected public secondary schools in Hulu Langat will be executed. Questionnaires will be distributed to 481 students on aggression as the dependent variable, and several independent variables: demographic (ethnicity, family income), biological (sex, head injury, nutritional deficiency, breakfast skipping), psychological (attitude and normative beliefs, personality trait, emotional intelligence), and so- cial factors (family environment, single parent status, domestic violence, peer deviant affiliation, alcohol, smoking, substance abuse). Subsequently, participants with moderate to high aggression scores will be further explored on the contextual factors of adolescent aggression by in-depth interview. Multiple linear regression will be executed using SPSS to determine significant predictors whereas thematic analysis will be applied for qualitative data analysis on the context of adolescent aggression. Both findings will be further integrated and discussed to give comprehensive description on the phenomena. Conclusion: Better knowledge and understanding on adolescent aggression may generate new framework to drive more effective preventive strategies and unravel adolescent aggressive related Pub- lic Health problems.
Introduction: The use of crude herbs for well-being as well as curation and prevention of ailments is evident globally, including Malaysia. To understand the effectiveness and reliability, the presence of phytochemical compounds as the factor influencing the use of crude herbs shall be determined. This study was conducted to screen the presence of phytochemical compounds in the local crude herbs consumed by patients with chronic diseases. This is part of
a larger study, where a cross-sectional study was conducted and reported elsewhere. Methods: In total, 15 types of crude herbs were reported by the patients with chronic diseases attending government health clinic at Kampar, Perak. The herbs were extracted using hot and standard cold methods respectively. Results: All the 15 crude herbs’ hot and cold extracts revealed the presence of eight phytochemical compounds, namely, phenols, quinones, tannins, terpenoids, saponins, flavonoids, glycosides, and alkaloids at varying intensity. Saponins, alkaloids, and glycosides were present in all the crude herbs extracts. However, terpenoids, tannins, and phenols were absent in Orthosiphon stamineus, Clinacanthus nutans, and Pandanus amaryllifolius extracts respectively. However, the cold extracts exhibited a higher intensity of phytochemicals compared to hot extracts. The present study confirms the presence of
phytochemicals in the local crude herbs consumed by patients with chronic diseases. The screened phytochemicals are bioactive compounds that possess medicinal properties that may trigger the patients to treat their diseases’ underlying conditions. However, the use of prescribed medicine, particularly among aging patients must be taken into account while consuming crude herbs. Conclusion: The findings of this study indicate that structured-evidence based crude herbs use interventions for patients with chronic diseases is warranted.
Adherence to antiretroviral therapy (ART) prevents disease progression, and the emergence of resistant mutations. It also reduces morbidity, and the necessity for more frequent, complicated regimens which are also relatively more expensive. Minimum adherence levels of 95% are required for treatment success. Poor adherence to treatment remains a stumbling block to the success of treatment programs. This generates major concerns about possible resistance of the human immunodeficiency virus (HIV) to the currently available ARVs. This paper aims to describe baseline results from a cohort of 242 Malaysian patients receiving ART within the context of an intervention aimed to improve adherence and treatment outcomes among patients initiating ART. A single-blinded Randomized Controlled Clinical Trial was conducted between January and December, 2014 in Hospital Sungai Buloh. Data on socio-demographic factors, clinical symptoms and adherence behavior of respondents was collected using modified, pre-validated Adult AIDS Clinical Trials Group (AACTG) adherence questionnaires. Baseline CD4 count, viral load, weight, full blood count, blood pressure, Liver function and renal profile tests were also conducted and recorded. Data was analyzed using SPSS version 22 and R software. Patients consisted of 215 (89%) males and 27 (11%) females. 117 (48%) were Malays, 98 (40%) were Chinese, 22 (9%) were Indians while 5 (2%) were of other ethnic minorities. The mean age for the intervention group was 32.1 ± 8.7 years while the mean age for the control group was 34.7 ± 9.5 years. Mean baseline adherence was 80.1 ± 19.6 and 85.1 ± 15.8 for the intervention and control groups respectively. Overall mean baseline CD4 count of patients was 222.97 ± 143.7 cells/mm³ while overall mean viral load was 255237.85 ± 470618.9. Patients had a mean weight of 61.55 ± 11.0 kg and 61.47 ± 12.3 kg in the intervention and control groups, respectively. Males account for about 90% of those initiating ART in the HIV clinic, at a relatively low CD4 count, high viral load and sub-optimal medication adherence levels at baseline.
Introduction: Illness perceptions involve personal beliefs that patients have about their illness and may influence health behaviour considerably. This preliminary study evaluates the understanding of illness perception among cardiac patients’ and correlations of each of the items. Methods: A preliminary study was conducted using the on Brief Illness Perception Questionnaire (BIPQ) in a tertiary hospital among 40 cardiac patients. Ethical approval was obtained from the institution ethical committee. There are 9 items in the BIPQ with 0-10 response scale measuring causal factors and an open-ended item. Items 1 to 5 assesses on the cognitive illness perception which comprises of consequences, timeline, personal control, treatment control and identity. Item 6 and 8 are on emotional response and item 7 is on coherence. Results: The overall mean score of the 8 items of BIPQ was 7.04 (1.07) with the highest mean for item 4 on treatment control and item 6 on personal control at 8.02 (0.92) and 7.03 (1.77) respectively while the lowest mean was item 7 on understanding at 6.63 (1.83). The causal factor for the open-ended question was mostly on consumption of fatty food intake, sedentary lifestyle and stress at work. Perceiving personal control was significantly being affected by perceiving treatment control for the cardiac disease (r=0.50) and being concerned about their cardiac symptoms was significantly related to perceiving consequences of the disease (r =0.54), perceiv- ing identity (r=0.75) and perceiving emotional control (r=0.67). Perceiving emotional control on their symptoms was significantly related to perceived consequences on cardiac disease (r=0.51), perceived identity (r=0.53) and perceived concern on cardiac disease (r=0.67). Conclusion: The results shown significant correlations with relevant outcomes measures. It is useful in clinical practice to assess and potentially modify patient’s perceptions on under- standing, emotional control, personal control, consequences and perceived concerned over their cardiac disease.
Background: Quality of Work Life (QWL) is a subset of the quality of life which expresses the interactions between workers and their total working environment with individual or human dimension. Objectives: The objective of this study was to determine the prevalence of QWL among Malaysian workers. Methods: 2740 respondents (1921 males and 819 females) were randomly selected from 11 different industries from all states of Malaysia. Respondents were aged between 18 to more than 55 years and were a local OSH Personnel and local general workers. Face to face interviews were conducted in all the selected industries using a structured questionnaire form adapted from Malaysian OSH Profile 2016. Respondents have completed the questionnaire under instructions and supervision of the research team. Results: Majority of the respondents were male (70.1%) and from manufacturing industries (76.3%). 50% of the respondents identified a high level of QWL in each component like not having a stress with the work load (85.5%), good work environment (78.4%), family life (83.1% and 83.6%), enough income and distribution (58.9%), good communication and harmonies relationship between colleagues and boss (93.4% and 88.7%), good facilities (88.6%), welfare at work (71.3%) and productive working condition (80.8%). There is a significant difference between QWL and type of industries [F(10)=12.897, p=0.001] where agriculture industry had the highest QWL. There is significant difference between QWL and gender (p=0.009) where male reported higher QWL compared to female. Conclusion: These findings could be used by the organizations in order to enhance its performance, productivity, employees’ commitment and satisfaction.
Introduction: A jinn possession model from the Islamic epistemology is discussed and its role in causing inter-psyche and intra-psyche conflicts. An analysis of the symptoms of jinn possession can also help differentiate jinn possession from mental disorders. Methods: An analysis of 34 symptoms of jinn possession, derived from symptoms used by globally established ruqyah experts, was conducted using quantitative approach. Out of the 1088 participants, 530 were diagnosed as having jinn possession. Their symptoms were analysed using Exploratory Factor Analysis (EFA) with Principal Component extraction method and Varimax rotation. Results: Some cases of mental health disorders can also be diagnosed as jinn possession according to ruqyah practitioners. The EFA analysis of the symptoms ex- tracted 6 factors associated with jinn possession i.e. “abnormal thoughts”, “faith delusion”, “scary dreams”, “sleep disturbances”, “low mood” and “hallucinations”. Conclusion: Some mental disorders may also be cases of jinn possession. Jinn possession refers to any disorder with an underlying jinn possession factor. “Faith delusion” can be used to distinguish jinn possession from mental disorders. The findings can act as a foundation for the development of a model for jinn possession that will lead to the development of an instrument for the diagnosis of jinn possession.
Introduction: Polymetabolic syndrome is a malady encompassing centralized accumulation of lipids and subsequent resistance to insulin leading towards diabesity. Currently, this condition is perilous threat to public health and also, creating perplexity for medical scientists. There is an intensive need for the development of obese rodent model having close resemblance with human metabolic syndrome (MetS); so that intricate molecular and/or therapeutic
targets can be elucidated. The resultant simulations will be beneficial to explicate not only pathogenesis but also secret conversation of signaling pathways in inducing MetS related complications in other organs. Methods: Currently, there are different methods for the development of rodent models of MetS, for instance, utilizing high lipogenic diet, genetic alterations, induction by chemicals or by combination of high fat diet and few others. In general, combination of cafeteria or western diet and low dose of streptozotocin (STZ) is a fine example of diet induced experimental model. In this model animals are allowed free access to highly palatable, energy dense, unhealthy human food for 12-18 weeks which promotes voluntary hyperphagia resulting in weight gain, increased fat mass and insulin resistance. At the end of feeding period 30mg/kg STZ is given intraperitoneally to mimic human type 2 diabetic condition.
Conclusion: Consumption of cafeteria diet with low dose STZ is considered to be the robust model of diabesity offering an exceptional stage to investigate the genomic, molecular, biochemical and cellular mechanisms of obesity and type 2 diabetes.
Introduction: Systemic inflammation is the major clinical problem which is constellation of communicable and non-communicable infection equipped with acute to chronic inflammation. It may lead to unfavourable conditions for instance, systemic inflammatory syndrome, burns and sepsis. Systemic inflammation might rotate the steering towards vital clinical maladies including cardiomyopathy, neuroinflammation, hepatitis, liver and kidney diseases and even diabetes. In order to elucidate the molecular insights in these clinical implications, there is an intensive need
to design rodent model of systemic inflammation having close association with systemic inflammatory conditions in humans. Methods: Presently, lipopolysaccharide (LPS) induced systemic inflammatory rodent model is widely established, reproducible and acceptable among scientists. In this model animals are treated with intraperitoneal injection of LPS ranging from 1-10 mg/kg which leads to instant release of proinflammatory cytokines to provide robust model of systemic inflammation in order to elucidate pathological conditions and their in-depth mechanism to uncover the new anti-inflammatory therapeutic targets. Conclusion: Robust model would open new window to explore anti-inflammatory activities of phytochemicals, small molecules and drug candidates along with crosstalk of different signaling pathways at molecular level.
Introduction: Health care involves team work. Physicians, nurses, pharmacists and social workers need to work in collaboration to deliver quality health care. It is therefore vital that team work and collaboration are integrated into the training of medical students. In a medical school where interprofessional education has not been introduced, the preclinical students are trained in silos whereas the clinical students have interprofessional experiences in hospital and community centers. This study was conducted to explore medical student’s receptiveness for interprofessional education and to identify any differences in attitude among the preclinical and clinical year students. Methods: This study adopted a cross-sectional study design using purposive sampling technique at a private medical school in Malaysia. Participants completedthe standardized Readiness for inter-professional learning Scale and the data was analyzed. Results: 436 students witha mean age of 22 years participated in this study. Among them, 170 were from preclinical and 266 were from clinical years Both the groups scored high on team work while clinical students scored better than preclinical students in understanding professional identity and recognizing their roles. Conclusion: This study shows a readiness among medical students for IPE. Clinical year medical student’s attitude was similar to preclinical students.
Introduction: Colorectal cancer is one of the top three most commonly occurring cancer worldwide with more than 1.8 million cases in 2018. In Malaysia, colorectal cancer is the most common cancer in males and the second most common cancer in females. Albeit being the second most common form of cancer in Malaysia, there is a lack of a formal or structured national colorectal cancer screening programme in Malaysia and it remains a low priority in healthcare planning and expenditure in Malaysia. The risk of developing colon cancer is greatly influenced by factors such as lifestyle habits, genetic inheritance, diet, weight, and exercise. Kras, the most frequently mutated oncogene in cancer, occurs in about 50 percent of colorectal cancers. Methods: This study maps the kras gene involved in colon cancer pathway, using bioinformatics applications such as STRING version 11.0 and Cytoscape version 3.7.0 to provide a clear visualisation of all the related and involved proteins and genes that interact with this kras gene in the pathway. Results: The 3391 protein interactions were assembled and visualized in y organic form. Six spe-cific non-overlapping clusters of various sizes, which emerged from the huge network of protein-interactors using MCODE version 1.32 clustering algorithm were found. Biological Networks Gene Ontology (BiNGO) was used to determine two ontologies (molecular function and biological process) involved in the protein network. Based on the resulting protein-protein network interaction map, each interaction plays an important role in the cell cycle, meta-bolic pathways and signal transduction. Conclusion: Understanding these interactions provide insight into cellular activities and thus assist in the understanding of the aetiology of disease.
Discrepancies between tooth sizes can cause orthodontic problems such as crowding and improper occlusion. By identifying these problems, better orthodontic treatment outcome can be achieved. The aim of this study is to identify anterior tooth size discrepancies among 4 different types of malocclusion i.e. Class I; Class II division 1 (II/1); Class II division 2 (II/2); and Class III. Methods: A retrospective study was carried out using 200 orthodontic study models where 50 study models were taken for each of the 4 malocclusion groups. The samples were selected using random sampling technique based on the orthodontic waiting list in the Orthodontic Department, Dental Faculty, UKM. All anterior teeth were measured by the same examiner at the largest mesio-distal dimension, using a digital caliper recorded up to 0.01 mm. Comparison between the 4 groups of malocclusion were made intra-arch using individual tooth size measurement and inter-arch using Anterior Bolton Index (ABI). Results: For the intra-arch assessment, Class II/1 had significantly the largest upper and lower anterior tooth size except for its upper canine and lower central incisor. Class III group had insignificantly the smallest mandibular anterior teeth compared to other malocclusion groups. For inter-arch assessment, Anterior Bolton Index (ABI) of all samples was 79.2 ± 3.94%. The highest ABI was noted in Class II / 2 of 80.3 ± 4.71%. However, no significant differences were found among the 4 malocclusion groups (p>0.05). Conclusion: Most of the anterior teeth in Class II division 1 were the largest of all. No significant difference in the inter-arch tooth size discrepancies were detected among all malocclusion
groups.
Introduction: Morinda citrifolia or also known as noni is commonly consumed raw or blanched as side dishes or ‘ulam’. As cancer is one of the most leading causes of death in the world, we aimed to evaluate the anti-prolifera- tive potential of noni shoot against various types of cancer cell lines. Methods: The breast cancer (MDA-MB-231), liver cancer (HepG2), and colorectal cancer (HT-29) cell lines were treated with 70% ethanol extract of noni shoot for cytotoxicity testing using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis induction effects were examined using AO/PI dual fluorescent assay and cell cycle analysis using flow cytometry. Gas chromatography-mass spectrometry (GCMS) was also carried out to characterize the active compounds in noni shoot. Results: The cytotoxicity assay demonstrated noni shoot had IC50 of 49.72 µg/mL, 307.5 µg/mL and 65.43 µg/ mL against MDA-MB-231, HepG2, and HT-29 cell lines, respectively. The AO/PI staining showed apoptotic bodies such as cell blebbing, chromatin condensation, and nuclear fragmentation was markedly induced in the selected cancer cell lines-treated with noni shoot extract. Apoptosis induction by noni shoot was showed by a significant increase in sub G0/G1 phase in MDA-MB-231 and HT-29 cell lines of cell cycle analysis. It was found that noni shoot extract contained mostly acetic acid and ethriol that may contribute to its anti-cancer properties. Conclusion: These findings showed the potential anticancer properties of noni shoot extract thereby, further studies are needed to un- derstand the mechanism of noni as anti-cancer agent and possibility to be developed as a nutraceutical or functional food products.
Introduction: Detecting breast cancer at earlier stage is crucial to increase the survival rate. Mammography as the golden screening tool has shown to be less effective for younger women due to denser breast tissue. Infrared Ther- mography has been touted as an adjunct modality to mammography. Further investigation of thermal distribution in breast cancer patient is important prior to its clinical interpretation. Therefore, thermal profiling using 3D compu- tational simulation was carried out to understand the effect of changes in size and location of tumour embedded in breast to the surface temperature distribution at different breast densities. Methods: Extremely dense (ED) and pre- dominantly fatty dense (PF) breast models were developed and simulated using finite element analysis (FEA). Pennes’ bioheat equation was adapted to show the heat transfer mechanism by providing appropriate thermophysical prop- erties in each tissue layer. 20 case studies with various tumour size embedded at two asymmetrical positions in the breast models were analysed. Quantitative and qualitative analyses were performed by recording the temperature values along the arc of breast, calculating of temperature difference at the peaks and comparing multiple thermal images. Results: Bigger size of tumour demands a larger increase in breast surface temperatures. As tumour is located far from the centre of the breast or near to the edge, there was a greater shift of temperature peak. Conclusion: Size and location of tumour in various levels of breast density should be considered as a notable factor to thermal profile on breast when using thermography for early breast cancer detection.
Introduction: Previous studies reported that a two-week double-dose clopidogrel treatment following percutaneous coronary intervention has no difference in safety compared to standard therapy. This study aimed to determine the all-cause readmission rate and survival after a year of percutaneous coronary intervention (PCI) in patients who were treated with two-week double-dose clopidogrel regimen. Methods: This was a retrospective study on patients who underwent PCI in a state general hospital in Malaysia in 2014. Patients’ one month and one-year survival status were retrieved using the hospital electronic patient management system. Patients who received a two-week course of 150mg clopidogrel and subsequently a one-year course of standard double antiplatelet therapy were included. Results: A total of 381 out of 563 patients who underwent PCI were included in the analysis, while those who were switched to ticagrelor and transferred to other hospitals post-PCI excluded. Patients had a mean age of 56.9 (SD 10.7), with majority male (331, 86.9%) and Malay (144, 37.8%). The PCI was mainly indicated for ST-elevated myocardial infarction (188, 49.3%), non-STEMI (114, 29.9%) and unstable angina (36, 9.4%). A total of 107 (28.1%) patients were readmitted within the one year post-PCI period. Readmissions were mainly due to ACS (55.5%) and bleeding events (2.4%). The 30-day and 1-year all-cause mortality was 33 cases and 43 cases, respectively. Conclu- sion: The low readmission and bleeding related readmission suggested that the two-week double-dose clopidogrel regimen was safe for the post PCI patients. Future randomised trial to establish the efficacy of this dosing regimen is therefore warranted.
Lipoma arborescens is a non-neoplastic, reactive condition due to chronic synovial inflammation and irritation, characterized by frond-like or villous proliferation of mature adipose tissue covered by hyperplastic synovium. The knee is the most commonly affected site particularly the suprapatellar pouch. We report a case of lipoma arborescens affecting the right knee of an elderly Chinese gentleman associated with bilateral knee and hand osteoarthritis. He presented with progressive worsening of right knee swelling and pain. Partial synovectomy of the right knee was performed and no lesion recurrence was noted at one year post-operation. The clinical and imaging findings, pathological features, together with differential diagnoses were discussed.
Group B streptococcus (GBS) is generally known to cause severe disease in the neonate and immunocompromised adults. GBS in the pregnant mother is rare and can potentially be fatal. Clinical presentation can be as mild as an uncomplicated urinary tract infection or serious invasive disease in the form of bacteremia, chorioamnionitis, endometritis and septic abortion. We report a case of a 46-year-old Para 3 lady, post-partum day 12, whom was found dead at home. Prior to her death, she had intermittent fever and abnormal lochia. Autopsy findings indicate GBS endometritis and bacteraemia. She was never screened for GBS. The cost-effectiveness of universal GBS screening needs to be explored to reduce maternal and neonatal morbidity due to GBS.
Introduction: Needlestick injuries (NSIs) are common occupational hazards against healthcare workers (HCWs). NSIs led to serious economic burden as there were high costs forhealth system and the society, as well as the psycholog-ical impact on exposed workers post injury. Methods: A retrospective cohort study was conducted to determine the incidence, contributing factors of NSIs and to estimate the cost of PEM in Sabah’s tertiary hospitals. Descriptive statis-tics were used to analyse and describe the trends of NSIs. Chi-Square test was performed to determine the association between variables, relative risk was calculated. Results: 145 cases out of 7075 employees were reported from 2017 to 2018. Results in this study showed that the highest incidence of NSIs was 2.4/100 employees in Hospital Queen Elizabeth. 1.1/100 employees in 2018, which was higher compared to year 2017. Most common among younger age group between 20-29 years old, among doctors, with median working experience of 2 years. NSIs occurred com-monly at the wards, during blood taking, disposal of devices and common device used were hypodermic needles. There was a lack of awareness on NSI precaution guidelines among the doctors (χ2=19.304, df=1, p=
Introduction: Increase in antibiotic resistance (ABR) worldwide, specifically in developing countries, requires the need to pay attention to self-medicated antibiotics, perception and attitude of ABR. Self-medication on antibiotics practices have a major pitfall, which is that users do not follow a prescribed course of drug and may usually stop the drug regimen once they feeling better. The spread of ABR is known to be associated with inadequate dosing, and incomplete courses which increases the actual cost of treating illnesses and social burden. This research is motivated by the alarming spread of ABR in Malaysia, the paucity of data on self-medication with antibiotics, and the alarming rate of pharmacy or drug stores that sell antibiotics and prescription-only medicines that are unauthorized to do so. Thus, the study has been done to observe the pattern of antibiotics usage of undergraduate students in a public uni- versity. Methods: Quantitative study with cross-sectional study have been chosen in this study and the target sample is localUniversiti Malaysia Sarawak(UNIMAS) undergraduate students with use of convenience sampling method. Besides, data collection has been done at main library (Centre for Academic Information Services)of UNIMASand students pavilion, UNIMAS by using the fully English online and hardcopy self-administered questionnaire adapted from previous study. Then, the data collected has been analysed by using SPSS Version 22. Results: In this study, 30.5% out of 403respondents have admitted that have taken antibiotics within 6 months and common reason of taking antibiotics given are fever, respiratory tract infection, and pain. Besides, there are 36% of respondents are not compliance to their antibiotics once prescribed with reason of already felt better and healed from the illness. More than 50% of the respondents are believed that antibiotics can treat the viral infection and work on the cold or coughs. For the attitude’s aspect, more than 60% of the respondents are expecting the doctor to prescribed them antibiotics when they are having cold symptoms and 49.9% will take antibiotics when they get cold to help them recover more quickly. Conclusion: This study has showed that there about a quarter of respondents (36%) still using antibiotics in improper method of consumption. Besides, some of the respondents have misunderstanding perception toward anti- biotics and bad attitudes on compliance toward the antibiotics. Thus, this problem from the young adult population could contributes to the increasing trend of antibiotics resistance in Malaysia.